An improved synthesis of N6-(6-aminohexyl)FAD

Article abstract of DOI:10.1080/15257779508012450

We report an improved synthesis of N⁶-(6-aminohexyl)FAD (1) using an efficient one-pot conversion of inosine to the N-trifluoroacetyl protected N⁶-(6-aminohexyl)adenosine 3. The 5'-O-phosphorylated AMP derivative 4, activated as the imidazolide, was coupled with commercial sodium riboflavin phosphate by using 18-crown-6 in DMF.

Full text of DOI:10.1080/15257779508012450

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Nucleosides and Nucleotides
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An Improved Synthesis of N6-(6-
Aminohexyl)FAD
Ashty Saleh a , Frans Compernolle a & Gerard Janssen b
a Laboratorium voor Organische Synthese , K. U. Leuven
Celestijnenlaan 200F , B-3001, Leuven-Heverlee, Belgium
b Rega Instituut , Minderbroedersstraat 10, B-3000, Leuven, Belgium
Published online: 16 Feb 2007.
To cite this article: Ashty Saleh , Frans Compernolle & Gerard Janssen (1995) An Improved Synthesis
of N6-(6-Aminohexyl)FAD, Nucleosides and Nucleotides, 14:3-5, 689-692
To link to this article: http://dx.doi.org/10.1080/15257779508012450
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