Mg(OH)2-Facilitated Liquid-Phase Conversion of Lactic Acid into 1,2-Propanediol over Cu: An Experimental and Theoretical Study

Article abstract of DOI:10.1002/cssc.201902347

Mg(OH)₂ is found to exhibit superior performance in the liquid-phase conversion of lactic acid (LA) into 1,2-propanediol over Cu. A conversion of 90 % with a selectivity of 98 % is achieved at 513 K and 5 MPa H₂. Mg(LA)₂ could be identified as a crucial intermediate in this reaction, as it undergoes faster conversion than the combination of LA and Mg(OH₂) and regeneration of Mg(OH)₂ through the conversion of Mg(LA)₂ as a substrate. DFT calculations reveal that the energetic span of the reaction decreases from 46.6 kcal mol^?1 catalyzed with no cation to 43.6 kcal mol^?1 with [Mg(OH)]⁺, confirming the facilitating effect of Mg(OH)₂.

Full text of DOI:10.1002/cssc.201902347

C105 BRONCHIECTASIS: FROM CLINICAL PHENOTYPES TO TREATMENT / RAPiD: Rapid Abstract Poster Discussion
Session / Tuesday, May 21/2:15 PM-4:15 PM / Ballroom A Four (Level 2), KBHCCD
Risk Factors for Haemoptysis in 1804 Adults with Non-Cystic Fibrosis
Bronchiectasis in Southwestern China: A Retrospective Cohort Study
X. Wang, B. Liu, J. Luo, D. Wang, C. Liu; West China Hospital of Sichuan University, Chengdu,
China.
Corresponding author's email: wangxhdoctor@163.com
Introduction/rationale: Non-cystic fibrosis bronchiectasis (here after referred to bronchiectasis) is
a chronic airway disease characterized by irreversible dilatation and distortion of the airway
lumens. Haemoptysis is a common symptom and even a life-threatening event for bronchiectasis
patients, especially for massive haemoptysis. Due to the lack of relative studies and the clinical
values, we summarized the characteristics of adult patients with bronchiectasis in southwestern
China. We aimed to identify the risk factors for haemoptysis and massive haemoptysis in adults
with non-cystic fibrosis bronchiectasis.Methods: From January 2009 to July 2017, patients with
documented bronchiectasis were retrospectively included. Clinical, laboratorial, and radiological
data were recorded and analysed using logistic regression analyses to determine potential risk
factors for both haemoptysis and massive haemoptysis. The baseline demographics consisted of
age, body mass index (BMI), gender, smoking status (divided into current smokers, ex-smokers,
and non-smokers), alcohol consumption history (divided into drinkers, never drinkers), age of
onset, duration of bronchiectasis symptoms, tuberculosis history, and morbidities, the presence of
bacteria in cultured sputum sample.Results: A total of 1804 patients with bronchiectasis were
finally inclueded. The prevalence of haemoptysis and massive haemoptysis among patients with
bronchiectasis was 62.5% and 7.1%, respectively. In the univariate logistic regression, potential
risk factors for haemoptysis were age, smoking status, age of onset, tuberculosis history, types of
bronchiectasis, Reiff score, number of diseased lung lobes and the rate of positivity of
Pseudomonas aeruginosa (PA) in sputum culture. However, only age (18-65) (OR = 1.655; P <
0.001), current smoking (OR = 2.085; P < 0.001), tuberculosis history (OR = 2.048; P < 0.001),
and non-diffuse bronchiectasis (OR = 1.675; P < 0.001) were identified as independent risk
factors for haemoptysis after multivariate logistic regression. Similarly, several factors for massive
haemoptysis were found to be significant in the univariate logistic regression including age,
gender, smoking status, alcohol consumption, age of onset, Reiff score, and the rate of positivity
for PA in sputum culture. But multivariate logistic regression resulted in only age (18-65 years)
(OR = 1.664; P = 0.033) and current smoking (OR = 1.945; P = 0.015) being independent risk
factors for massive haemoptysis (Table 1).Conclusion: For non-cystic fibrosis bronchiectasis in
southwestern China, patients with age between 18 and 65 years, current smoking, a history of
tuberculosis and the presence of non-diffuse bronchiectasis are at risk of haemoptysis or even
massive haemoptysis.

This abstract is funded by: None
Am J Respir Crit Care Med 2019;199:A5711
Internet address: www.atsjournals.org
Online Abstracts Issue