Palladium-catalyzed regio- and stereoselective synthesis of N-protected 2,4-dialkylated azacyclobutanes from amino allenes

Article abstract of DOI:10.1016/S0040-4039(99)01517-8

Palladium-catalyzed reaction of N-arylsulfonyl-1-alkyl-3,4-dienylamines with an aryl iodide in the presence of potassium carbonate in DMF at around 70°C affords most predominantly the 2,4-cis-disubstituted azacyclobutanes bearing an aryl group on the doub