The synthesis of nicotinic acid-7-13C

Article abstract of DOI:10.1002/jlcr.2580140614

Nicotinic acid, an intermediate in the pyridine nucleotide cycle, was labeled with ¹³C at the 7 position. The reaction of CuCN-¹³C (prepared from NaCN-¹³C) with 3-bromopyridine, followed by hydrolysis to the acid and purification by ion exchange chromatography, gave an overall yield of 72% nicotinic acid 7-¹³C. This greater than 3-fold increase in yield over previous methods is the result of in situ hydrolysis of the nitrile intermediate.