Synthesis of N-demethyl-N-substituted dihydroisomorphine and dihydroisocodeine derivatives

Article abstract of DOI:10.1080/00397919208020486

Several new N-demethyl-N-alkyl derivatives (1p, 1r, 1s, 1m, 1n and 1o) of dihydroisomorphine and dihydroisocodeine, and N-demethyl-N-cyclopropylmethylisocodeine (2g) have been prepared. The presented synthetic procedure allows a convenient access to a series of structurally related, stereochemically homogeneous substances for studies of the agonist/antagonist properties.

Full text of DOI:10.1080/00397919208020486

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Synthetic Communications: An
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Synthesis of N-
Demethyl-N-Substituted
Dihydroisomorphine and
Dihydroisocodeine Derivatives+
Sándor Hosztafi a , Csaba Simon a & Sándor Makleit b
a ALKALOIDA Pharmaceutical Works Rt. , H-4440,
Tiszavasvári, Hungary
b Department of Organic Chemistry , L. Kossuth
University , H-4010, Debrecen, Hungary
Published online: 23 Sep 2006.
To cite this article: Sándor Hosztafi , Csaba Simon & Sándor Makleit (1992) Synthesis
of N-Demethyl-N-Substituted Dihydroisomorphine and Dihydroisocodeine Derivatives+
, Synthetic Communications: An International Journal for Rapid Communication of
Synthetic Organic Chemistry, 22:12, 1673-1682, DOI: 10.1080/00397919208020486
To link to this article: http://dx.doi.org/10.1080/00397919208020486
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