Bioorganic and Medicinal Chemistry Letters p. 5375 - 5377 (2005)
Update date:2022-08-29
Topics:
Gavalda, Sabine
Braga, Remi
Dax, Chantal
Vigroux, Alain
Blonski, Casimir
Dihydroxyacetone-phosphate and phosphonate derivatives were synthesized bearing a N-sulfonyl hydroxamate moiety. The phosphate derivatives represent competitive inhibitors for the class II-FBP aldolase catalyzed reaction, while the phosphonate isosteres are comparatively weaker inhibitors.
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