Rhodium-catalyzed reaction of N-acylpiperazines with CO and ethylene. Carbonylation at a C-H bond directed by an amido group

Article abstract of DOI:10.1016/S0040-4039(97)01738-3

The reaction of N-acylpiperazines with CO (15 atm) and ethylene at 160°C in the presence of Rh₄(CO)₁₂ results in dehydrogenation and carbonylation at a C-H bond. This reaction represents the first example of carbonylation at a C-H bo