Bioorganic Chemistry p. 1 - 4 (2014)
Update date:2022-08-11
Topics:
Olomola, Temitope O.
Mosebi, Salerwe
Klein, Rosalyn
Traut-Johnstone, Telisha
Coates, Judy
Hewer, Raymond
Kaye, Perry T.
A series of seven novel, rationally designed N-substituted 3-{3,5-dimethylfuro[3,2-g]coumarin-6-yl}propanamides have been prepared as potential HIV-1 integrase (IN) inhibitors via a five-step pathway commencing with resorcinol and diethyl 2-acetylglutarate, and the HIV-1 IN inhibition potential of these compounds has been examined relative to raltegravir, a known HIV-1 IN inhibitor.
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