Bioorganic and Medicinal Chemistry Letters p. 1949 - 1952 (1999)
Update date:2022-08-11
Topics:
Chu, Min
Mierzwa, Ronald
He, Ling
King, Arthur
Patel, Mahesh
Pichardo, John
Hart, Andrea
Butkiewicz, Nancy
Puar, Mohindar S.
A new hepatitis C virus (HCV) protease inhibitor designated as Sch 351633 (1) was isolated from the fungus, Penicillium griseofulvum. Structure elucidation of 1 was accomplished by analysis of spectroscopic data, which determined compound 1 to be a bicyclic hemiketal lactone. Compound 1 exhibited inhibitory activity in the HCV protease assay with an IC50 value of 3.8 μg/mL.
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