A second generation photochemically activatable dynemicin analog: A concise synthesis and DNA cleavage studies

Article abstract of DOI:10.1055/s-1994-25681

A scheme for the design of dynemicin analogs and a concise, efficient route for their synthesis are described. A photochemically activatable analog was prepared and shown to undergo cycloaromatization upon irradiation with wavelengths greater than 300 nm. The ability of this compound to function as a competent DNA cleaving agent is demonstrated.