Journal of labelled compounds and radiopharmaceuticals p. 19 - 28 (2002)
Update date:2022-08-18
Topics:
Mathew
Ravi
Sontakke
Chander
Unprotected deoxyadenosine 1 was treated with an excess of phosphorus acid and stoichiometric proportions of N, N′-di-p- tolylcarbodiimide in anhydrous pyridine to give deoxyadenosine-5′-monophosphite 2. The latter wax activated with trimethylsilyl chloride followed by sulphurisation with elemental 35S (specific activity > 1000 Ci/mmol) in toluene solution to give deoxyadenosine5′-(35S)-thiomonophosphate [dAMP(35S)] 3. Enzymatic conversion of deoxyadenosine-5′-(35S)-thiomonophosphate to Sp-deoxyadenosine-5′-(α-35S)-thiotriphosphate [Sp-dATP (α-35S)] 5 was carried out following a standard reaction protocol. Copyright
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