Journal of Medicinal Chemistry p. 1010 - 1013 (1981)
Update date:2022-08-24
Topics:
Bristol, James A.
Gold, Elijah H.
Gross, Irwin
Lovey, Raymond G.
Long, James F.
A series of 9-<(aminoalkyl)thio>-9H-xanthenes (3-6) and 5-<(aminoalkyl)thio>-5H-<1>benzopyrano<2,3-b>pyridines (7-10) possessing gastric antisecretory activity in the rat and dog is described.Many of the compounds possessed good activity in the pylorus-ligated rat and several inhibited histamine-stimulated gastric acid secretion in the dog.The mechanism of acid secretion inhibition is not related to anticholinergic or histamine (H2) receptor antagonism.
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