Synthesis of biologically active drimanes and homodrimanes from (-)-sclareol

Article abstract of DOI:10.1016/0040-4020(95)00370-N

Three drimanes, polygodial (2), albicanyl acetate (3) and 7-oxo-8,12-drimen-11-al (5), and two homodrimanes, 13,14,15,16-tetranorlabd-7-en-12,17-dial (6) and 7-oxo-13,14,15,16-tetranorlabd-8(17)-en -12-al (7), were synthesized from (-)-sclareol (1), and their antifeedant, antitumor and antimicrobial properties tested. In most cases, 6 and 7 were found to be more active than 2.