A novel one-step synthesis of quinolinium salts and 4-quinolones from formanilides

Article abstract of DOI:10.1016/S0040-4039(00)73654-9

N-Methylformanilide in POCl₃ reacts readily at 80°C with alkanoamides(RCH₂CONR′₂) to give 3-R-4-chloroquinolinium salts in good yields. The arylamide reacts as its Vilsmeier salt and the alkanoamide as an α-chloroenamine. High yields of 4-quinolones are easily obtained by base treatment.