Synthesis of 1-[cis-2-hydroxy-cis-3-(hydroxymethyl)-cyclobutyl]thymine, a novel method for the synthesis of cyclobutyl nucleosides and related compounds

Article abstract of DOI:10.1080/15257779408013238

Syntheses of 1-[cis-2-hydroxy-cis-3-(hydroxymethyl)cyclobutyl]thymine (1) and related compounds by a novel method are reported. Coupling of 3- benzyloxymethyl-1-cyclobutene (2) with silylated thymine in the presence of NIS, followed by treatment with DBU, basic hydrolysis and catalytic hydrogenation produced the target compound (1) and its isomer (12).

Full text of DOI:10.1080/15257779408013238

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Nucleosides and Nucleotides
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Synthesis of 1-[cis-2-Hydroxy-cis-3-
(hydroxymethyl)-cyclobutyl]thymine,
a Novel Method for the Synthesis of
Cyclobutyl Nucleosides and Related
Compounds
a
a
a
Tai-Shun Lin , Mei-Zhen Luo & Mao-Chin Liu
a
Department of Pharmacology and Comprehensive Cancer Center ,
Yale University School of Medicine , New Haven, Connecticut, 06510
Published online: 23 Sep 2006.
To cite this article: Tai-Shun Lin , Mei-Zhen Luo & Mao-Chin Liu (1994) Synthesis of 1-[cis-2-
Hydroxy-cis-3-(hydroxymethyl)-cyclobutyl]thymine, a Novel Method for the Synthesis of Cyclobutyl
Nucleosides and Related Compounds, Nucleosides and Nucleotides, 13:1-3, 245-254, DOI:
10.1080/15257779408013238
To link to this article: http://dx.doi.org/10.1080/15257779408013238
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