APPLICATION OF THE COMBINATION OF SODIUM BISULFITE AS A PROTECTIVE REAGENT AND SOLID SUPPORTS IN THE SELECTIVE REDUCTION OF 4-ACETYLBENZALDEHYDE WITH DIBORANE

Article abstract of DOI:10.1246/cl.1981.1657

4-Acetylbenzaldehyde (2) has been selectively reduced by using a combination of protective group and solid supports.The formyl group of 2 was protected by addition of sodium bisulfite.The adduct, supported on silica gel, was then selectively reduced to 4-