Reduction of Ketones by Tributyltin Hydride: The Effect of High Pressure on Steric Hindrance and Rearrangement Processes

Article abstract of DOI:10.1021/jo00360a008

The reduction of sterically hindered ketones by tributyltin hydride under high pressure (1 GPa) afforded the corresponding alcohols in good yields without the need of free radical initiator or Lewis acid catalyst.Cyclopropyl ketones and α,β-epoxy ketones were also reduced in high yields under 1400 MPa with preservation of the three-membered ring.