The cleavage of the 2,2,2-trichloro-1,1-dimethylethoxycarbonyl protective group by tin(II) tris(benzenethiolate)

Article abstract of DOI:10.1055/s-1991-26452

The cleavage of the 2,2,2-trichloro-1,1-dimethylethoxycarbonyl (trichloro-tert-butoxycarbonyl, TCBOC) protective group for amino and hydroxy functions by tin(II) tris[benzenethiolate] in the presence of tetrabutylammonium cobalt(II) phthalocyanine-5,12,19,26-tetrasulfonate is reported. This combination is superior to previously used deblocking reagents for the TCBOC-group.