Mild and Regiospecific Phosphorylation of Nucleosides

Article abstract of DOI:10.1055/s-1997-950

Nucleosides are reported to be conveniently phosphorylated by diphenylphosphate previously activated with a triarylphosphine-I₂ complex. The reaction is characterised by mild conditions, high yields, easy work-up and purification of the final product. The activation of the phosphorylating agent, unlike Mitsunobu reaction, enables to avoid the usual inversion of configuration at C-3′.