Synthesis of 2-hydroxy-3-methyl-2-cyclo-pentenone, corylone, from 2-ketoglutaric acid

Article abstract of DOI:10.1080/00397919108021577

Treatment of 2-ketoglutaric acid with diazomethane gave 2-(methoxycarbonyl)-oxiranepropanoic acid methyl ester (2) which lead to 2-hydroxy-2-methyl-glutaric acid dimethyl ester (3) by catalytic hydrogenation, which was further processed to the title compound.

Full text of DOI:10.1080/00397919108021577

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Synthesis of 2-Hydroxy-3-
methyl-2-cyclo-pentenone,
Corylone, from 2-
Ketoglutaric Acid
a
Maria Lucília dos Santos & Gouvan C. de
a
Magalhães
a
Department de Química, Universidade de
Brasília, 70.910, Brasília, DF, Brasil
Version of record first published: 24 Sep 2006.
To cite this article: Maria Lucília dos Santos & Gouvan C. de Magalhães
1991): Synthesis of 2-Hydroxy-3-methyl-2-cyclo-pentenone, Corylone, from 2-
(
Ketoglutaric Acid, Synthetic Communications: An International Journal for Rapid
Communication of Synthetic Organic Chemistry, 21:17, 1783-1788
To link to this article: http://dx.doi.org/10.1080/00397919108021577
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