A concise and efficient novel synthesis of cleviolide

Article abstract of DOI:10.1080/00397919908085969

Cleviolide I has been synthesized in 73 % overall yield by a short reaction sequence involving the preparation of 4-methyl-1-trimethylsilylpent- 3-en-1-yne 7 from trimethylsilylethynylzinc chloride 6 and 1-bromo-2- methylpropene 5, the direct conversion of 7 into the corresponding 1- tributylstannyl derivative 8 and the Pd-catalysed reaction of this organotin derivative with 4-bromofuran-2(5H)-one 10.

Full text of DOI:10.1080/00397919908085969

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Synthetic Communications: An
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Chemistry
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A Concise and Efficient Novel
Synthesis of Cleviolide
Renzo Rossi a , Fabio Bellina a & Matteo Biagetti a
a Dipartimento di Chimica e Chimica Industriale - Università
di Pisa, Via Risorgimento 35, 1-56126, Pisa, Italy
Version of record first published: 17 Sep 2007
To cite this article: Renzo Rossi, Fabio Bellina & Matteo Biagetti (1999): A Concise and
Efficient Novel Synthesis of Cleviolide, Synthetic Communications: An International Journal
for Rapid Communication of Synthetic Organic Chemistry, 29:19, 3415-3420
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