A convenient one-step synthesis of 2-hydroxy-1,3,5-benzenetricarbaldehyde

Article abstract of DOI:10.1080/00397910008086933

The hexamethylenetetramine/trifluoroacetic acid system was demonstrated to be capable of introducing three aldehyde groups into the phenol molecule. Facile, one-step procedures were developed for the preparation of hitherto difficult to synthesize 2-hydroxy-1,3,5-benzenetricarbaldehyde starting from either phenol or 4-hydroxybenzaldehyde. New pKa measurements showed 2-hydroxy-1,3,5-benzenetricarbaldehyde to be an acid stronger than previously reported.

Full text of DOI:10.1080/00397910008086933

This article was downloaded by: [Dalhousie University]
On: 08 December 2012, At: 20:38
Publisher: Taylor & Francis
Informa Ltd Registered in England and Wales Registered Number: 1072954
Registered office: Mortimer House, 37-41 Mortimer Street, London W1T 3JH,
UK
Synthetic Communications: An
International Journal for Rapid
Communication of Synthetic
Organic Chemistry
Publication details, including instructions for
authors and subscription information:
http://www.tandfonline.com/loi/lsyc20
A Convenient One-Step
Synthesis of 2-Hydroxy-1,3,5-
Benzenetricarbaldehyde
Andrew A. Anderson a , Thomas Goetzen a , Scott A.
Shackelford a & Stella Tsank a
a Agouron Pharmaceuticals, Inc., Alanex Division,
3550 General Atomics Court, San Diego, California,
92115
Version of record first published: 04 Dec 2007.
To cite this article: Andrew A. Anderson, Thomas Goetzen, Scott A. Shackelford
& Stella Tsank (2000): A Convenient One-Step Synthesis of 2-Hydroxy-1,3,5-
Benzenetricarbaldehyde, Synthetic Communications: An International Journal for
Rapid Communication of Synthetic Organic Chemistry, 30:17, 3227-3232
To link to this article: http://dx.doi.org/10.1080/00397910008086933
PLEASE SCROLL DOWN FOR ARTICLE
Full terms and conditions of use: http://www.tandfonline.com/page/terms-
and-conditions
This article may be used for research, teaching, and private study purposes.
Any substantial or systematic reproduction, redistribution, reselling, loan,
sub-licensing, systematic supply, or distribution in any form to anyone is
expressly forbidden.

The publisher does not give any warranty express or implied or make any
representation that the contents will be complete or accurate or up to
date. The accuracy of any instructions, formulae, and drug doses should be
independently verified with primary sources. The publisher shall not be liable
for any loss, actions, claims, proceedings, demand, or costs or damages
whatsoever or howsoever caused arising directly or indirectly in connection
with or arising out of the use of this material.