An Efficient Synthesis of Conjugated Trienoic Acids via Stille Cross Coupling Reaction of (E)-1,2-Bis(tributylstannyl)ethylene

Article abstract of DOI:10.1055/s-1997-5746

Stereoselective construction of conjugated trienoic acids was achieved through two successive Stille reactions, coupling as the first step (E)-1,2-bis(tributylstannyl)ethylene and tributylstannyl-3-iodoalk-2-enoates. The second step can be conducted by two different routes: 1) cross-coupling of the stannyldienoic acid reagents 2 and vinyliodides or 2) cross-coupling of vinyltin reagents and tributylstannyl 5-iodopenta-2,4-dienoates generated by iododestannylation of stannyldienes 2.