A Strategy to Control the Reactivation of Frustrated Lewis Pairs from Shelf-Stable Carbene Borane Complexes

Article abstract of DOI:10.1002/anie.201505974

N-Phosphine oxide substituted imidazolylidenes (PoxIms) have been synthesized and fully characterized. These species can undergo significant changes to the spatial environment surrounding their carbene center through rotation of the phosphine oxide moiety. Either classical Lewis adducts (CLAs) or frustrated Lewis pairs (FLPs) are thus formed with B(C₆F₅)₃ depending on the orientation of the phosphine oxide group. A strategy to reactivate FLPs from CLAs by exploiting molecular motions that are responsive to external stimuli has therefore been developed. The reactivation conditions were successfully controlled by tuning the strain in the PoxIm-B(C₆F₅)₃ complexes so that reactivation only occurred above ambient temperature. Frustration under control: Imidazolylidenes with a phosphine oxide substituent on one of the nitrogen atoms can undergo drastic changes to the spatial environment surrounding their carbene center through rotation of the phosphine oxide moiety. Depending on the orientation of this group, either classical Lewis adducts or frustrated Lewis pairs (FLPs) are formed upon addition of B(C₆F₅)₃.

Full text of DOI:10.1002/anie.201505974

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Angewandte
Communications
International Edition: DOI: 10.1002/anie.201505974
German Edition: DOI: 10.1002/ange.201505974
Frustrated Lewis Pairs
A Strategy to Control the Reactivation of Frustrated Lewis Pairs from
Shelf-Stable Carbene Borane Complexes
Yoichi Hoshimoto,* Takuya Kinoshita, Masato Ohashi, and Sensuke Ogoshi*
À
Abstract: N-Phosphine oxide substituted imidazolylidenes
(PoxIms) have been synthesized and fully characterized.
These species can undergo significant changes to the spatial
environment surrounding their carbene center through rotation
of the phosphine oxide moiety. Either classical Lewis adducts
(CLAs) or frustrated Lewis pairs (FLPs) are thus formed with
B(C6F5)3 depending on the orientation of the phosphine oxide
group. A strategy to reactivate FLPs from CLAs by exploiting
molecular motions that are responsive to external stimuli has
therefore been developed. The reactivation conditions were
successfully controlled by tuning the strain in the PoxIm–
B(C6F5)3 complexes so that reactivation only occurred above
ambient temperature.
enthalpically strong H H bond. Since the landmark report
from Stephan et al.,[4] the chemistry of FLPs has been rapidly
developed with a variety of LBs, such as phosphines,[2e]
carbenes,[2f] and nitrogen bases.[2g] Furthermore, several
intermolecular systems showing thermally induced frustration
have been reported.[5–7] Thermally induced FLPs can be
considered as “reactivated” frustrated pairs derived from
quenched CLA precursors, but such processes were previ-
ously generally induced at ambient temperature.[6,7a–e] To
date, few reports have focused on the development of
a strategy to control the reactivation conditions of FLPs
from CLAs by using external stimuli. As CLAs are often
isolable and shelf-stable, well-controlled thermally induced
systems would enable the generation of active FLPs whenever
necessary. Therefore, the development of a method to restore
the FLP reactivity from a quenched CLA under accurately
controlled reaction conditions rather than under ambient
conditions should expand both the utility and versatility of
Lewis pair systems.[7f–h]
G
iven the growing importance of economic and sustainable
chemical processes, chemists have been continuously devot-
ing their efforts to the development of homogeneous systems
for molecular transformations with earth-abundant ele-
ments.[1] As such, much attention has recently been paid to
the utilization of frustrated Lewis pairs (FLPs) owing to the
promising advantages of employing harmless and abundant
main-group elements.[2] FLPs are recognized as weakly bound
noncovalent complexes comprising an electron acceptor
(Lewis acid, LA) and an electron donor (Lewis base, LB),
in which the formation of classical Lewis adducts (CLAs) is
encumbered by steric repulsion between LA and LB.[2,3]
Whereas the typical chemical features of both the LA and
the LB are usually quenched through the formation of CLAs,
FLPs exhibit a much higher reactivity and can activate the
Herein, we describe a strategy to control the reactivation
of an active FLP species from shelf-stable CLAs by making
use of external stimuli-responsive molecular motions. Our
strategy for designing a novel FLP system focused on the
utilization of N-heterocyclic carbenes (NHCs)[8] and
B(C6F5)3,[9] both of which have played important roles in
modern organic synthesis. Pioneering reports by Stephan
et al.[10] and Tamm et al.[11] disclosed that NHCs bearing
N-tBu groups reacted with B(C6F5)3 to give FLPs; however,
the reported NHC-based FLPs easily lost their activity
through
a rearrangement to abnormal carbene–borane
[*] Dr. Y. Hoshimoto, T. Kinoshita, Prof. Dr. M. Ohashi,
Prof. Dr. S. Ogoshi
adducts or decomposition, thereby significantly limiting
their utility.[2f] An intriguing progress has recently been
reported by Tamm and co-workers, who found that the
treatment of 1,3-di-tert-butylimidazolin-2-ylidene (ItBu)
with tris[3,5-bis(trifluoromethyl)phenyl]borane, B(XyF6)3,
Department of Applied Chemistry, Faculty of Engineering
Osaka University
Suita, Osaka 565-0871 (Japan)
E-mail: hoshimoto@chem.eng.osaka-u.ac.jp
ogoshi@chem.eng.osaka-u.ac.jp
À
resulted in complexation to give [ItBu B(XyF6)3], which
reacted with 0.5 equivalents of H2 at room temperature to
Dr. Y. Hoshimoto
À
À À
give [ItBu H][(XyF6)3B H B(XyF6)3] along with the loss of
one ItBu.[7a] Herein, we designed a novel NHC keeping the
following considerations in mind (Figure 1): 1) The substitu-
Frontier Research Base for Global Young Researchers
Graduate School of Engineering, Osaka University
Suita, Osaka 565-0871 (Japan)
Prof. Dr. S. Ogoshi
JST, ACT-C
Suita, Osaka 565-0871 (Japan)
Supporting information for this article is available on the WWW
under http://dx.doi.org/10.1002/anie.201505974.
ꢀ 2015 The Authors. Published by Wiley-VCH Verlag GmbH & Co.
KGaA. This is an open access article under the terms of the Creative
Commons Attribution Non-Commercial NoDerivs License, which
permits use and distribution in any medium, provided the original
work is properly cited, the use is non-commercial and no modifica-
tions or adaptations are made.
Figure 1. Design of a CLA that can be reactivated into an FLP.
11666
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phosphine oxide and the carbene.
À
The P N2 bond length is 1.719(1) Š,
which is slightly shorter than that
found in 3-(di-tert-butylphosphino)-
1-(2,6-diisopropylphenyl)imidazole-
2-ylidene
(NHCPDipp
,
1.7485-
(16) Š).[12,13] In the 13C NMR spectra
of 2a–2c, the resonances of the
carbene carbon were observed at
2
approximately 220 ppm with JC,P
values of 25.0 Hz, which are almost
the same as those frequently encoun-
tered with unsaturated NHCs.[8]
The impact of the rotation of the
À
phosphine oxide around the N P
bond on the spatial environment
surrounding the carbene center was
evaluated based on the percent
buried volume (%Vbur),[14,15] which
was calculated using the structural
parameters of 2a–2c obtained from
DFT and X-ray analyses (Figure 2c).
These compounds exhibit a relatively
large degree of steric bulkiness in
conformer A. Variations in the free
energy were then scanned by chang-
ing the angle of ]C-N-P-O starting
from conformer A (]C-N-P-O
ꢀ 1808). The theoretical activation
Figure 2. a) Synthesis of PoxIm·HOTf salts (1) and PoxIm carbenes (2). Yields of isolated products
are given. The dC/2JC,P (ppm/Hz) values given are those of 2 measured in C6D6. b) Molecular
structure of 2a; ellipsoids set at 30% probability. Hydrogen atoms are omitted for clarity.
c) Conformation exchange of PoxIm between conformers A and B. DFT calculations were conducted
at the B3LYP/6-31G+ +(d,p) level of theory (gas-phase, 258C). Calculated ]C-N-P-O values [8] for
conformer A: 2a: 178.5, 2b: 180.0, 2c: 178.6; for conformer B: 2a: 19.4, 2b: 23.0, 2c, 22.2. DE8
(kcalmolÀ1) is the relative free energy of B with respect to A. DE° (kcalmolÀ1) is the calculated
activation energy barrier from A to B. [a] The %Vbur values were determined from crystallographic
parameters.
ent on one of the nitrogen atoms should include both large
(RL) and small (RS) units on the connecting atom (RC);
2) drastic changes in the spatial environment surrounding the
carbene center should be induced by rotation around the
energy barrier of the rotation (DE°) is approximately
+ 12 kcalmolÀ1 at 258C, showing that the rotation would
take place easily. Furthermore, the existence of conformer B
(]C-N-P-O ꢀ 208), for which the %Vbur value is smaller than
for conformer A, was predicted to be possible as a metastable
state; however, the relative energy of conformer B is much
higher than that of conformer A (DE8 =+ 9.2–9.5 kcalmolÀ1).
These results indicate that PoxIms exist predominantly as
conformer A at 258C and can change their steric bulkiness by
rotation of the phosphine oxide.
À
N RC bond to permit for the formation of both CLA and FLP
species; and 3) the interconversion between the CLA and the
FLP should be brought about by external stimuli.
These designs led us to prepare the carbenes PoxIm
(Figure 2a). The synthesis of the carbene precursors,
PoxIm·HOTf (1a–1c), followed a pathway that was previ-
ously developed by Kostyuk et al.[12] and Hofmann et al.[13] to
prepare N-phosphanyl-substituted imidazolium salts. Without
isolation of these air-sensitive imidazolium species, oxidation
of the N-phosphanyl group with aqueous H2O2 gave 1a–1c,
which were isolated as bench-stable solids.[14] The structures
of these products were confirmed by NMR spectroscopy and
high-resolution mass spectrometry, and 1a was also analyzed
by X-ray crystallography (Supporting Information, Fig-
ure S1). The molecular structure of 1a shows that the
Treatment of 2a with B(C6F5)3 in CD2Cl2 at À908C
resulted in the quantitative formation of 3a, in which the
phosphine oxide coordinates to B(C6F5)3 (Figure 3). In the
31P NMR spectrum, the resonance of the phosphine oxide is
observed at 79.2 ppm and has thus been shifted downfield
through the complexation in comparison with that of 2a
(63.0 ppm).[16] Furthermore, the chemical shift of the carbene
carbon is 219.5 ppm (2JC,P = 30.2 Hz), indicating that the
complexation does not occur at the carbene center as the
chemical shift is almost the same as that of 2a (220.5 ppm,
2JC,P = 25.0 Hz). The results of the 1H, 11B, and 19F NMR
analyses also support the formation of 3a at À908C.[14]
Elevating the temperature to 258C led to the conversion of
3a into carbene borane complex (B-Pox) 4a in 72% yield.
When the reaction of 2a with B(C6F5)3 was conducted at room
temperature in toluene, 4a was isolated as a white solid in
95% yield (Figure 3). Owing to the restricted rotation around
phosphine oxide group is almost in the same plane as the
a
À
=
imidazolium ring, and that the C H and P O bonds are
oriented in the same direction (]C-N-P-O = 5.4(5)8). Treat-
ment of 1a–1c with KOtBu in THF resulted in the deproto-
nation of Ha and yielded PoxIm derivatives 2a–2c in excellent
yields. All of these carbenes can be isolated as colorless
crystals after recrystallization from THF/hexane solution at
À308C. The molecular structure of 2a is shown in Figure 2b.
=
À
The P O bond and the lone pair of the carbene unit are
the carbene–borane and N P bonds at room temperature on
oriented in an anti fashion (]C-N2-P-O = 175.9(1)8), pre-
sumably to avoid the repulsion between the lone pairs of the
the NMR timescale, each of the four iPr and two tBu groups is
observed independently in the 1H and 13C NMR spectra,
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generation of the FLP (kinetic CLA!FLP), and the FLP
would be converted into 4a along with rotation of the
phosphine oxide (FLP!thermodynamic CLA).[3]
In the solid state, no decomposition of 4a was observed
after 16 weeks at 20–308C even in the presence of air and
moisture (25–35% humidity). This stability of 4a evokes the
reactivity of a quenched Lewis acid–base adduct; however,
under thermal conditions, the FLP reactivity was perfectly
restored. For example, at 608C, 4a activated H2 quantitatively
for three hours in CH2Cl2, thus affording 5a, which was
isolated in 99% yield (Figure 5). 5a was also produced
Figure 3. Two types of complexation between 2a and B(C6F5)3 giving
3a and 4a, respectively. The yields were determined by NMR spectros-
copy. [a] Yields of isolated products. The molecular structure of 4a is
also shown; ellipsoids are set at 30% probability, and hydrogen atoms
are omitted for clarity. Selected bond distances [Š] and angles [8]: C–B
1.696(3), N2–P 1.779(2), P–O 1.470(2); C-N2-P 131.7(2), C-N2-P-O
7.2(2).
while fifteen resonances are observed in the 19F NMR
spectrum. The resonance of the phosphine oxide is observed
at 76.0 ppm in the 31P NMR spectrum. Furthermore, the
structure of 4a was confirmed by X-ray crystallography,
illustrating the rotation of the phosphine oxide from an anti
(]C-N2-P-O = 175.9(1)8 in 2a) to a syn arrangement (]C-
N2-P-O = 7.2(2)8 in 4a). The %Vbur value of the PoxIm
moiety in 4a was calculated to be 30.3 based on experimental
Figure 5. Thermally induced frustration systems with 4a–4c. The yields
were determined by NMR spectroscopy. [a] CH2Cl2 was used as the
solvent. [b] Yields of isolated products. [c] C6H5Br was used as the
solvent.
parameters, which is
a
significant decrease from the
%Vbur value of free 2a (53.0, see above).[15d,e] The C B
À
bond length is 1.696(3) Š, and thus slightly longer than those
quantitatively at 408C (72 h); however, at 258C (72 h), no
product was observed. These results demonstrate the occur-
rence of a thermally induced frustration process in this system
at temperatures above room temperature (see also
Scheme S1).[7]
[10]
À
À
measured for both [IPr B(C6F5)3] (1.663(5) Š), and [ItBu
B(XyF6)3] (1.675(4) Š).[7a] Furthermore, the boron atom in 4a
is located 0.43 Š out of the imidazolium plane, which is
À
comparable with the arrangement in [ItBu B(XyF6)3]
À
(0.47 Š), but clearly differs from that of [IPr B(C6F5)3]
The temperature required to induce the reactivation of
FLPs from B-Pox was successfully controlled by tuning the
strain in the B-Pox component (see below). As demonstrated
in Figure 5, complex 4b activated H2 to yield 5b quantita-
tively in 1,2-dichloroethane at 808C, whereas 5b was only
formed in 6% yield at 608C after three hours. In the case of
4c, heterolytic H2 cleavage took place efficiently in C6H5Br at
1208C to give 5c quantitatively, whereas only 3 and 7% of 5c
were formed in 1,2-dichloroethane after three hours at 80 and
1008C, respectively. These results suggest that B-Pox com-
plexes with a larger strain can operate at lower reaction
temperatures to activate H2 than complexes with less strain;
the degree of strain was evaluated based on the values of r
(distance between B and the imidazolium plane), r’ (distance
between P and the imidazolium plane), and the length of the
(0.23 Š). No significant interaction is observed between the O
and B atoms in the solid structure (B···O = 3.234(3) Š).
Heterolytic cleavage of H2 was observed at room temper-
ature when H2 gas was pressurized into a solution of 2a and
B(C6F5)3 in CH2Cl2 within three minutes of mixing to give 5a
in 45% yield with the concomitant formation of 4a in 38%
yield (Figure 4). This result indicates the in situ generation of
an FLP species that yielded 5a and 4a through H2 activation
and the formation of a carbene–borane bond, respectively. It
is noteworthy that the FLP comprising 2a and B(C6F5)3 can
activate H2 at 258C once it has been generated in situ. Based
on these results, 3a should be formed in situ prior to the
À
C B bond (Figure 6a).
The FLP reactivation process in this work is illustrated in
Figure 6b. First, rotation of the phosphine oxide would occur
followed by dissociation of B(C6F5)3 from the carbene center.
In these processes, the B(C6F5)3 moiety is driven away from
the carbene center by the steric demand of the tBu groups
along with the rotation of the phosphine oxide.
Figure 4. H2 activation at room temperature with a combination of 2a
and B(C6F5)3. Yields were determined by NMR spectroscopy.
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Figure 6. a) Comparison of the molecular structures of 4a–4c. The values are those of the DFT optimized structures (at the M06-2X/6-311G(d,p)
level of theory for the gas-phase molecules). [a] Value determined from crystallographic parameters. b) Possible reactivation of FLPs from B-Pox.
Ar=C6F5. c) Selected properties of the optimized structures of states I–III and 6c and their relative Gibbs free energies at 1208C. [b] Calculated
activation energy barrier (kcalmolÀ1) from III to 6c.
To confirm the impact of the rotation of the phosphine
oxide on the reactivation of the FLPs, variable-temperature
(VT) NMR experiments were conducted with 4c in C6D5Br
from 30 to 908C, which revealed that the phosphine oxide,
N-aryl, and B(C6F5)3 groups in 4c can rotate more easily at
higher temperatures (Figures S12–S14). The influence of the
rotation of the phosphine oxide on the structure of 4c was
evaluated by DFT calculations at the M06-2X/6-311G(d,p)
level of theory by scanning the ]C-N-P-O angle starting from
state I (]C-N-P-O = 3.08), which is the optimized structure of
4c (Figure 6c). State II is a saddle point, and state III is
metastable; both were found through the scanning process
and have molecular structures drastically different from
state I. The highest-energy state was found to be state II
(DG =+ 29.9 kcalmolÀ1, ]C-N-P-O = 96.98) where the boron
atom is located 0.63 Š out of the imidazolium plane while the
phosphorus atom remains almost in the plane. In state III,
(DG =+ 19.8 kcalmolÀ1, ]C-N-P-O = 161.18), the boron and
phosphorus atoms are located at r= 0.79 and r’ = 0.65 Š,
respectively, indicating the increase in strain that is due to the
steric repulsion between the tBu groups on the phosphine
oxide and the C6F5 groups. This strain can be somewhat
approximately Æ 1008 at the temperature in which the FLP
species is not fully reactivated, rationalizing the dynamic
behavior observed by VT NMR spectroscopy, and further
rotation would prompt decomplexation.
A potential-energy surface scan with respect to the
distance between the carbene carbon and boron atoms was
conducted from both state I and III of 4c. A metastable
energy state (6c) was found at C···B = 3.8 Š from state III,
which can be regarded as an encounter complex consisting of
2c and B(C6F5)3 (Figure 6c and Figure S21), whereas such
a state was not found from state I.[14] These results again
manifest the importance of the rotation of the phosphine
oxide for the reactivation of the FLP species. The theoretical
activation energy barrier for the reactivation process to give
6c (I!III!6c) is DGsum° =+ 35.8 kcalmolÀ1 at 1208C.
Under the experimental conditions, dissociation of B(C6F5)3
might partially proceed during the rotation of the phosphine
oxide from state II to III.
For comparison, FLP reactivation was attempted for
[NHCPDipp B(C6F5)3] (7) in CD2Cl2 with H2 (5 atm), resulting
À
in no reaction at 608C, whereas harsher reaction conditions
(1008C) led to its decomposition (Scheme S2). These results
also demonstrate the importance of the phosphine oxide
moiety for reactivating the FLP species from 4a.
À
reduced through elongation of the N P bond, and such
À
a change of the N P bond length is obvious for state III
(4.4% elongation from I). Significant structural changes were
also observed upon further scanning from state III, which
imply that maintaining the carbene–borane bond is no longer
beneficial (Figure S18). According to these results, the
phosphine oxide moiety in 4c would rotate mainly within
The hydrogenation of N-benzylidene benzenesulfona-
mide (8) was conducted with 4c and H2 (5 atm) at 1208C to
demonstrate that the present system could be applied in
organic synthesis (Figure 7a).[1a,2a,b] After eight hours,
N-phenylsulfonyl benzylamine (9) had been formed quanti-
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Keywords: frustrated Lewis pairs · hydrogenation ·
N-heterocyclic carbenes · phosphine oxides
How to cite: Angew. Chem. Int. Ed. 2015, 54, 11666–11671
Angew. Chem. 2015, 127, 11832–11837
[1] For examples of hydrogenation reactions, see: a) D. W. Stephan,
Chem. Commun. 2010, 46, 8526; b) R. M. Bullock, Science 2013,
342, 1054; c) A. L. Kenward, W. E. Piers, Angew. Chem. Int. Ed.
2008, 47, 38; Angew. Chem. 2008, 120, 38; d) J. Paradies, Angew.
Chem. Int. Ed. 2014, 53, 3552; Angew. Chem. 2014, 126, 3624.
[2] For selected recent reviews, see: a) D. W. Stephan, Acc. Chem.
Res. 2015, 48, 306; b) D. W. Stephan, G. Erker, Angew. Chem.
Int. Ed. 2015, 54, 6400; Angew. Chem. 2015, 127, 6498; c) P. A.
Chase, A. L. Gille, T. M. Gilbert, D. W. Stephan, Dalton Trans.
2009, 7179; d) G. Erker, C. R. Chim. 2011, 14, 831; e) D. W.
Stephan, G. Erker, Top. Curr. Chem. 2013, 332, 85; f) E. L.
Kolychev, E. Theuergarten, M. Tamm, Top. Curr. Chem. 2013,
334, 121; g) V. Sumerin, K. Chernichenko, F. Schulz, M. Leskelä,
B. Rieger, T. Repo, Top. Curr. Chem. 2013, 332, 111.
Figure 7. a) Reactions of 4c with 8 in the presence of H2. b) Reaction
of 5c with 8. Yields were determined by 1H NMR spectroscopy.
tatively along with 5c in 95% yield. At 1508C, this reaction
reached completion within three hours to furnish 9 and 5c in
> 99 and 78% yield, respectively. To elucidate the ability of
5c to hydrogenate 8, the direct hydrogenation of 8 was also
conducted with isolated 5c, which was complete after
15 hours and gave 9 in 46% yield with the concomitant
formation of H2 in 15% yield (Figure 7b).[14] These results
show that 5c can mediate the hydrogenation of 8 to produce 9,
but it is also plausible that FLP species that consist of 8 (and/
or 9) and B(C6F5)3 and are formed by the in situ switching of
the Lewis base after reactivation of the FLP comprising 2c
and B(C6F5)3 might be involved as active species. Thus far, the
hydrogenation of unsaturated compounds with an NHC-
based FLP system has been considered to be very challenging
owing to the high proton affinity of NHCs.[2f] Our results show
that NHC-based FLPs can indeed be employed for the
hydrogenation of unsaturated compounds under appropriate
reaction conditions.
In summary, molecular motions that are responsive to
external stimuli can be used to reactivate frustrated Lewis
pairs from shelf-stable carbene borane complexes. Key to
success was the design of N-phosphine oxide substituted
imidazolylidenes (PoxIms) that can undergo drastic changes
to the spatial environment surrounding its carbene center.
Depending on the orientation of the phosphine oxide group,
either classical Lewis adducts or frustrated Lewis pairs are
formed with B(C6F5)3. The reactivation conditions were
successfully controlled to require higher than ambient
temperature by tuning the strain in the carbene borane
complexes. The impact of the rotation of the phosphine oxide
on FLP reactivation was evaluated experimentally as well as
theoretically, which confirmed this rotation to be critical. We
believe that the present system should contribute to the
realization of challenging molecular transformations by
making use of the high reactivity of NHC-based FLPs.
[3] T. A. Rokob, I. Pµpai, Top. Curr. Chem. 2013, 332, 157.
[4] G. C. Welch, R. R. San Juan, J. D. Masuda, D. W. Stephan,
Science 2006, 314, 1124.
[5] T. A. Rokob, A. Hamza, A. Stirling, I. Pµpai, J. Am. Chem. Soc.
2009, 131, 2029.
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based on phosphines or amines, see: a) X. Wang, G. Kehr, C. G.
Daniliuc, G. Erker, J. Am. Chem. Soc. 2014, 136, 3293; b) T.
Holtrichter-Rçßmann, C. Rçsener, J. Hellmann, W. Uhl, E.-U.
Würthwein, R. Frçhlich, B. Wibbeling, Organometallics 2012, 31,
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Bergander, B. Wibbeling, R. Frçhlich, G. Erker, Dalton Trans.
2009, 1534; e) P. Spies, G. Erker, G. G. Kehr, K. Bergander, R.
Frçhlich, S. Grimme, D. W. Stephan, Chem. Commun. 2007,
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Top. Curr. Chem. 2013, 332, 45.
[7] a) E. Kolychev, T. Bannenberg, M. Freytag, C. G. Daniliuc, P. G.
Jones, M. Tamm, Chem. Eur. J. 2012, 18, 16938; b) S. J. Geier,
D. W. Stephan, J. Am. Chem. Soc. 2009, 131, 3476; c) M. Ullrich,
A. J. Lough, D. W. Stephan, Organometallics 2010, 29, 3647; d) T.
Voss, T. Mahdi, E. Otten, R. Frçhlich, G. Kehr, D. W. Stephan,
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Fox, H. Berke, Organometallics 2011, 30, 2117; g) V. Sumerin, F.
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a
recent report describing an intriguing concept for the
protection of a reactive Lewis acidic moiety with a bulky
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Acknowledgements
This work was supported by Grants-in-Aid for Young
Scientists (A) (25708018), Encouragement for Young Scien-
tists (B) (15 K17824), and a Grant-in-Aid for Scientific
Research on Innovative Areas (15H00943, 15H05803, and
23105546) from MEXT. Y.H. acknowledges support from the
Frontier Research Base for Global Young Researchers,
Osaka University on the program of MEXT.
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ꢀ 2015 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
Angew. Chem. Int. Ed. 2015, 54, 11666 –11671

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[14] See the Supporting Information for details; %Vbur values were
calculated using the SambVca program with the following
parameters: sphere radius: 3.00 Š; distance for the metal–
ligand bond: 2.00 Š; H atoms were omitted; Bondi radii scaled
by 1.17.
Received: June 29, 2015
Published online: August 6, 2015
Angew. Chem. Int. Ed. 2015, 54, 11666 –11671
ꢀ 2015 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
www.angewandte.org 11671