Heterocyclo-substituted sulfa drugs: Part XI. Novel biologically active N-(piperidino-, morpholino-, piperazino-) dithiocarbamyl-azo dyes and their chelates

Article abstract of DOI:10.1080/10426500008046622

A Series of novel azo-sulfa drugs of piperidino-, morpholino-, mono-, and bis-piperazino-N-dithiocarbamyl-azo dyes (Ia-h - IV a-h) are synthesiezed via a reaction of 4-[(4′-heterocyclo-substituted) suflamoyl and/or sulfonyl] benzenediazonium salts with N-piperidino-, N-morpholino-, mono-, and bis- N-piperazino- dithiocarbamate sodium salts in acid medium to afford the corresponding azo dye legands. Interaction of these ligands with metal salts: iron(III), copper(II) and mercuric(II) chlorides in ethanolic solution afforded the corresponding metal chelates (I′a-h - ′IVa-h), (I″a-h - ″IVa-h) and (I?a-h - ≈IVa-h). Ligands and their metal chelates are characterized by microanalysis, IR, UV-Vis H-NMR spectroscopy and are screened in vitro for their antimicrobial activities. Chelation of ligands induces a remarkable increase in their antimicrobial activity.

Full text of DOI:10.1080/10426500008046622

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Phosphorus, Sulfur, and Silicon
and the Related Elements
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HETEROCYCLO-SUBSTITUTED
SULFA DRUGS: PART XI.
NOVEL BIOLOGICALLY
ACTIVE N-(PIPERIDINO-,
MORPHOLINO-, PIPERAZINO-)
DITHIOCARBAMYL-AZO DYES
AND THEIR CHELATES
a
Ibrahim M.A. Awad
a
Department of Chemistry, Faculty of Science,
University of Assiut, Assiut, 71516, Egypt
Published online: 04 Oct 2006.
To cite this article: Ibrahim M.A. Awad (2000) HETEROCYCLO-SUBSTITUTED
SULFA DRUGS: PART XI. NOVEL BIOLOGICALLY ACTIVE N-(PIPERIDINO-,
MORPHOLINO-, PIPERAZINO-) DITHIOCARBAMYL-AZO DYES AND THEIR CHELATES,
Phosphorus, Sulfur, and Silicon and the Related Elements, 163:1, 219-251, DOI:
10.1080/10426500008046622
To link to this article: http://dx.doi.org/10.1080/10426500008046622
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