-AZOXYBIS(METHYLENE) BIS(3-CHLOROBENZOATE): POTENT MUTAGEN FROM REACTION OF HEXAMETHYLPHOSPHORAMIDE, N-METHYLHYDROXYLAMINE AND -NITROSOMETHANE DIMER WITH 3-CHLOROPEROXYBENZOIC ACID

DOI: 10.1016/S0040-4039(00)88032-6

Source and publish data:

Tetrahedron Letters p. 2819 - 2820 (1983)

Update date:2022-08-15

Topics:

Authors:

Kimmel, Ella C.

Holden, Ian

Segall, Yoffi

Casida, John E.

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Article abstract of DOI:10.1016/S0040-4039(00)88032-6

-Azoxybis(methylene) bis(3-chlorobenzoate), an exceptionally potent mutagen (3050 revertants/nmol) in the Salmonella typhimurium (strain TA100) assay, is formed in trace (<1percent) quantity via -nitrosomethane dimer on treatment of hexamethylphosphoramide or N-methylhydroxylamine with 3-chloroperoxybenzoic acid.

Full text of DOI:10.1016/S0040-4039(00)88032-6

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