Platinum(II) Complexes of Functionalized Malonato Ligands: Unequivocal Synthesis, Interaction with a Tetradeoxyribonucleotide and Deoxyribonucleic Acid

DOI: 10.1039/DT9930002141

Source and publish data:

Journal of the Chemical Society, Dalton Transactions p. 2141 - 2146 (1993)

Update date:2022-08-16

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Authors:

Laurent, Jean-Pierre

Morvan, Bernard

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Article abstract of DOI:10.1039/DT9930002141

The unequivocal syntheses of four cis-> complexes has been achieved, avoiding any interaction between the pendant carboxyl group and the platinum.The complexes have been characterized by elemental analysis, 13C NMR and FAB mass spectroscopy.Their interaction with a tetradeoxyribonucleotide d(T-G-G-T) (G = guanosine, T = ribosylthymine) and DNA (in vitro) has been investigated to show that they form adducts of the type 7,N^7'>> as do the known therapeutically activeplatinum complexes.However, the presence of the free carbonyl function increases significantly the reactivity with respect to that of the non-functionalized malonato complexes >.

Full text of DOI:10.1039/DT9930002141

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