Journal of Medicinal Chemistry p. 7740 - 7753 (2006)
Update date:2022-08-17
Topics:
Morrell, Andrew
Antony, Smitha
Kohlhagen, Glenda
Pommier, Yves
Cushman, Mark
The biological activity of indenoisoquinoline topoisomerase I inhibitors is significantly enhanced by nitration of the isoquinoline ring. In the present study, nitrated analogues were synthesized with the indenone ring substituted with methoxy groups to f
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