Multifunctional hydrogel based on ionic liquid with antibacterial performance

Article abstract of DOI:10.1016/j.molliq.2019.112185

Biocompatible antibacterial hydrogels as novel dressing materials have been a widely researched method in modern medical technology. Here, we designed and prepared a new type of multifunctional antibacterial hydrogels that used poly(vinyl alcohol) (PVA)-tetrahydroxyborate anion (B(OH)₄ ^?) hydrogel as a vector and pyrrolidinium ionic liquids (ILs) as antibacterial drugs. The formation of borate ester bonds between PVA and B(OH)₄ ^? as dynamic network junctions endows hydrogels with multiple functions. Moreover, the as-prepared hydrogel exhibited effective anti-microbial activity against Escherichia coli and Staphylococcus aureus. Our results indicated that the hydrogels containing ILs with longer alkyl chain exhibited more pronounced antibacterial properties. The moisture retention, self-healing, syringeability and multiresponse behavior together with the antibacterial properties of the hydrogels make them ideal candidates as multifunctional dressing materials for joint skin wound healing.

Full text of DOI:10.1016/j.molliq.2019.112185

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Multifunctional hydrogel based on ionic liquid with antibacterial
performance
Yang Yu, Zeyu Yang, Shujing Ren, Yanan Gao, Liqiang Zheng
PII:
S0167-7322(19)33138-1
DOI:
https://doi.org/10.1016/j.molliq.2019.112185
MOLLIQ 112185
Reference:
To appear in:
Journal of Molecular Liquids
Received date:
Revised date:
Accepted date:
3 June 2019
27 September 2019
20 November 2019
Please cite this article as: Y. Yu, Z. Yang, S. Ren, et al., Multifunctional hydrogel based
on ionic liquid with antibacterial performance, Journal of Molecular Liquids(2019),
https://doi.org/10.1016/j.molliq.2019.112185
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Multifunctional hydrogel based on ionic liquid with antibacterial
performance
Yang Yu,a Zeyu Yang,c Shujing Ren,a Yanan Gao,*,b and Liqiang Zheng*,a
a
Key Laboratory of Colloid and Interface Chemistry, Shandong University, Ministry of
Education, Jinan, 250100, China
b
Key Laboratory of Ministry of Education for Advanced Materials in Tropical Island
Resources, Hainan University No 58, Renmin Avenue, Haikou, 570228, China
c China Research Institute of Daily Chemical Industry Co., Ltd. Taiyuan, Shanxi, CN 030000
*Corresponding author: Liqiang Zheng E-mail address: lqzheng@sdu.edu.cn
Yanan Gao E-mail address: ygao@hainanu.edu.cn
Abstract
Biocompatible antibacterial hydrogels as novel dressing materials have
been a widely researched method in modern medical technology. Here,
we designed and prepared a new type of multifunctional antibacterial
hydrogels that used poly(vinyl alcohol) (PVA)-tetrahydroxyborate anion
–
(B(OH)4 ) hydrogel as a vector and pyrrolidinium ionic liquids (ILs) as
antibacterial drugs. The formation of borate ester bonds between PVA and
–
B(OH)4 as dynamic network junctions endows hydrogels with multiple
functions. Moreover, the as-prepared hydrogel exhibited effective
anti-microbial activity against Escherichia coli and Staphylococcus
aureus. Our results indicated that the hydrogels containing ILs with
longer alkyl chain exhibited more pronounced antibacterial properties.
1

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The moisture retention, self-healing, syringeability and multiresponse
behavior together with the antibacterial properties of the hydrogels make
them ideal candidates as multifunctional dressing materials for joint skin
wound healing.
Keywords: Ionic liquid antibacterial hydrogels multifunctional dressing
materials
Introduction
The skin is the outermost organ of the body that protects the body from
the external environment.1 Skin wounds are susceptible to bacterial attack,
thus causing infection. Bacterial infection is one of the most common
clinical diseases; this type of infection can endanger human health and
even threaten human life.2 The ideal wound dressing would prevent the
wound from being further damaged and infected and accelerate the
healing process. In 1962, Dr. Winter first proposed a new concept of the
moisturizing environment of the wound that contributes to wound healing.
A moist wound bed prevents tissue dehydration and apoptosis and
promotes angiogenesis.3 Epithelial cells are more prone to migration in
humid compared with dry environments during wound healing, and the
growth factors in the wound fluid are more active in the environment
attached to occlusive dressing.4 However, traditional dressings, such as
cotton wool, bandages and gauzes, provide poor occlusion and tend to
promote water evaporation, resulting in a relatively open dehydrated
2

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wound bed.5, 6
Hydrogels have a 3D network structure through physical or chemical
crosslinking7-9 that absorbs a large amount water or biological fluids,
swells without structure destruction and provides a suitable 3D
environment and mechanical protection.10 In addition, hydrogels have
many features, such as good biocompatibility, adjustable strength and
flexibility, providing a broad application prospects in the biomedical
field.11, 12 As an improvement upon the traditional wound healing agents,
antibacterial hydrogels have become a research hotspot.
As research continues to advance, many advanced antibacterial
hydrogels with versatility have been developed. As an emerging category
of antibacterial materials, hydrogels with unique properties, such as
responsiveness13, 14 and self-healing, have been reported.15, 16 The design
of multifunctional and multiresponsive smart hydrogels with self-healing
and self-supporting properties in noncovalent systems has attracted
particular interest due to their wide applications in biotechnology,17
adaptability and reversibility.15 Dynamic covalent chemistry is one
method for the preparation of smart materials based on reversible
covalent bonds, which integrate both the stability of covalent bonds and
the reversibility of noncovalent bonds. Dynamic materials with
controllable structure and chemical properties have broad applications in
biomedical fields. The formation of borate ester by the reversible and
3