Preparation of 2,4-dihydroxybenzaldehyde by the Vilsmeier-Haack reaction

Article abstract of DOI:10.1080/00397919608003654

An efficient synthesis of 2,4-dihydroxybenzaldehyde (1) from resorcinol via the Vilsmeier-Haack reaction has been developed. Either phosphorous oxychloride/DMF or oxalyl chloride/DMF produces 1 in yields of 65-75%. The intermediate formamidinium salts have been characterized.

Full text of DOI:10.1080/00397919608003654

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Synthetic Communications:
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Synthetic Organic Chemistry
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Preparation of 2,4-
Dihydroxybenzaldehyde
by the Vilsmeier-Haack
Reaction
Wilford L. Mendelson a & Stuart Hayden a
a Synthetic Chemistry Department, SmithKline
Beecham Pharmaceuticals, Post Office Box
1539, King of Prussia, PA, 19406–0939
Published online: 21 Aug 2006.
To cite this article: Wilford L. Mendelson & Stuart Hayden (1996) Preparation
of 2,4-Dihydroxybenzaldehyde by the Vilsmeier-Haack Reaction, Synthetic
Communications: An International Journal for Rapid Communication of Synthetic
Organic Chemistry, 26:3, 603-610, DOI: 10.1080/00397919608003654
To link to this article: http://dx.doi.org/10.1080/00397919608003654
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