Analytical Chemistry
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aromatic protons from PCAD also showed a downfield shift
AUTHOR INFORMATION
Corresponding Author
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with 0.10 ppm. All these data confirmed the coordination of
hydrogen bonding between the host and guest molecules.
Moreover, the possible interaction modes were verified by
Gaussian simulations (Figure 5B, Figure S6 and supported
information). These model analyses revealed the critical role
of hydrogen boding between Tyr and PCAD. The binding
energies is -36.81 KJ/mol for Tyr. In contrast, it is only -16.02
KJ/mol for Phe (as a control), which indicated that the PCAD
prefers binding with Tyr. Both the results of NMR and
Gaussian simulations demonstrated that such CdSe-LQDs
displayed high selectivity for Tyr. Therefore, these results of
TEM, contact angle, NMR and Gaussian simulations could
both confirm that the possible mechanism is the hydrogen
interaction between the phenolic hhdroxyl group of Tyr and
the ester group/PEG chain from PCAD of LQDs.
*
Notes
The authors declare no competing financial interest.
ACKNOWLEDGMENT
This work was supported by National Natural Science Foundation
of China (21708012, 81600459, 51402099, 21874017), Wuhan
scientific and technological projects (2019020701011441),
NSFHP (2017CFB151, 2016CFB312) and Talent introduction
project of Hubei Polytechnic University (15xjz03R). Finally,
thanks to the Open Research Fund supported by CAS Key
Laboratory of Nano-Bio Interface (NO:19NBI01).
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In short, we have demonstrated a Tyr-responsive CdSe QDs
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