Trifluoromethylation of organic halides with methyl halodifluoroacetates - a process via difluorocarbene and trifluoromethide intermediates

Article abstract of DOI:10.1016/S0022-1139(00)80112-8

Treatment of methyl halodifluoroacetates, XCF2CO2Me (X=Cl, Br, I), with organic halides RY in the presence of KF and CuI at an appropriate temperature in DMF gave the corresponding trifluoromethylated derivatives, RCF3, in moderate to high yields.A process involving difluorocarbene and trifluoromethide intermediates is suggested.