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phosgene
9,10-dihydrodibenzazepine
10,11-dihydro-dibenzo[b,f]azepine-5-carbonyl chloride
Conditions | Yield |
---|---|
In toluene at 90 - 95℃; for 3.5h; | 90% |
With sodium hydroxide In chlorobenzene at 100 - 115℃; for 4h; | 80% |
With toluene | |
With toluene |
n-butyllithium
6-fluoro-3-[1-(3-hydroxypropyl)-4-piperidinyl]-1,2-benzisoxazole
B
10,11-dihydro-dibenzo[b,f]azepine-5-carbonyl chloride
Conditions | Yield |
---|---|
In hexane |
9,10-dihydrodibenzazepine
bis(trichloromethyl) carbonate
10,11-dihydro-dibenzo[b,f]azepine-5-carbonyl chloride
Conditions | Yield |
---|---|
With pyridine In 1,2-dichloro-ethane at 75℃; for 3h; Inert atmosphere; | |
With sodium hydroxide In chlorobenzene at 100 - 115℃; for 4.5h; | |
In chlorobenzene at 110℃; for 5h; Temperature; | |
With sodium hydrogencarbonate In dichloromethane at 0 - 20℃; for 12.5h; |
5,10-bis(2-nitrobenzenesulfonyl)-5,10-diaza-1,14-tetradecanediamine
10,11-dihydro-dibenzo[b,f]azepine-5-carbonyl chloride
Conditions | Yield |
---|---|
In dichloromethane at 20℃; for 19h; | 95% |
In dichloromethane at 20℃; |
10,11-dihydro-dibenzo[b,f]azepine-5-carbonyl chloride
5H-dibenz[b,f]azepine-5-carbonylchloride
Conditions | Yield |
---|---|
With sodium bromate; N-benzyl-N,N,N-triethylammonium chloride; bromine; dibenzoyl peroxide In chlorobenzene at 92 - 97℃; for 8.5h; Temperature; Reagent/catalyst; | 90.5% |
Multi-step reaction with 2 steps 1: Br2 / chlorobenzene / 1.5 h / 145 - 150 °C 2: chlorobenzene / 2 h / 150 - 155 °C View Scheme | |
With bromine In chlorobenzene at 80℃; for 6h; Temperature; Inert atmosphere; |
10,11-dihydro-dibenzo[b,f]azepine-5-carbonyl chloride
9,10-dihydrodibenzazepine
Conditions | Yield |
---|---|
In acetonitrile electrolysis (Et4NClO4, Hg-dropelectrode); | 90% |
Methyl-(1-methyl-[4]piperidyl)-amin
10,11-dihydro-dibenzo[b,f]azepine-5-carbonyl chloride
Conditions | Yield |
---|---|
With triethylamine In dichloromethane for 2h; Heating; | 90% |
10,11-dihydro-dibenzo[b,f]azepine-5-carbonyl chloride
10,11-Dihydrocarbamazepin
Conditions | Yield |
---|---|
With ammonia In methanol; water at 57 - 59℃; for 1.5h; | 85.35% |
With ethanol; ammonia | |
With ethanol; ammonia |
pyrrolidine
10,11-dihydro-dibenzo[b,f]azepine-5-carbonyl chloride
(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)(pyrrolidin-1-yl)methanone
Conditions | Yield |
---|---|
With triethylamine In benzene | 85% |
4-phenyl-1-piperazine
10,11-dihydro-dibenzo[b,f]azepine-5-carbonyl chloride
(11,12-dihydro-5H-dibenzo[b,f]azepin-5-yl)(4-phenylpiperazin-1-yl)methanone
Conditions | Yield |
---|---|
With triethylamine In 1,4-dioxane | 83% |
Molecular Structure:
Molecular Formula: C15H12ClNO
Molecular Weight: 257.7149
IUPAC Name: 5,6-Dihydrobenzo[b][1]benzazepine-11-carbonyl chloride
Synonyms of Iminodibenzylcarbonyl chloride (CAS NO.33948-19-5): EINECS 251-756-5 ; 10,11-Dihydro-5H-dibenz(b,f)azepine-5-carbonyl chloride
CAS NO: 33948-19-5
Product Categories: (intermediate of carbamazepine)
Melting point: 121-124 °C
Index of Refraction: 1.628
Molar Refractivity: 71.39 cm3
Molar Volume: 200.9 cm3
Surface Tension: 50.1 dyne/cm
Density: 1.282 g/cm3
Flash Point: 194.2 °C
Enthalpy of Vaporization: 64.79 kJ/mol
Boiling Point: 397.5 °C at 760 mmHg
Vapour Pressure: 1.58E-06 mmHg at 25°C
Iminodibenzylcarbonyl chloride (CAS NO.33948-19-5) is used as pharmaceutical intermediates.
Hazard Codes of Iminodibenzylcarbonyl chloride (CAS NO.33948-19-5): C
Risk Statements: 34
R34: Causes burns.
Safety Statements: 26-36/37/39-45
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR: UN 3261 8/PG 2
WGK Germany: 3
HazardClass: 8
PackingGroup: III