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123-75-1

Basic Information
CAS No.: 123-75-1
Name: Tetrahydro pyrrole
Molecular Structure:
Molecular Structure of 123-75-1 (Tetrahydro pyrrole)
Formula: C4H9N
Molecular Weight: 71.12
Synonyms: Pyrrolidin;Tetramethylenimine;Pyrrolidine ring;Perhydropyrrole;Pyrrole, tetrahydro-;2,3,4,5-Tetrahydropyrrole;Azacyclopentane;Butylenimine;Pyrrolidine (Tetrahydropyrrole);Pyrrolidine 99%;Pyrrolidine;Prolamine;
EINECS: 204-648-7
Density: 0.866 g/cm3
Melting Point: -63 °C, 210 K, -81 °F
Boiling Point: 89.451 °C at 760 mmHg
Flash Point: 2.778 °C
Solubility: Miscible with water
Appearance: Colourless to pale yellow liquid
Hazard Symbols: FlammableF,ToxicT,CorrosiveC
Risk Codes: 11-22-23-34-35-20/21/22-20/22
Safety: 16-26-36/37/39-45-33
Transport Information: UN 1922 3/PG 2
PSA: 12.03000
LogP: 0.69860
Synthetic route
109-97-7

pyrrole

123-75-1

pyrrolidine

Conditions
ConditionsYield
With 5% Ru/MgO; hydrogen In tetrahydrofuran at 150℃; under 38002.6 Torr; for 0.7h;100%
With dichloro(μ-chloro)(μ-hydrido)bis(η-p-cymene)diruthenium(II); hydrogen In neat (no solvent) at 90℃; under 60006 Torr; for 40h;89%
With Cp*Rh(2-(2-pyridyl)phenyl)H; hydrogen In neat (no solvent) at 100℃; under 27361.8 Torr; for 48h; Catalytic behavior; Glovebox;74%
56475-80-0

N-(methoxycarbonyl)pyrrolidine

123-75-1

pyrrolidine

Conditions
ConditionsYield
With tert-butylamine In methanol for 3h; Heating;100%
With methyllithium; lithium bromide In tetrahydrofuran at 0℃; for 1h;95%
78521-30-9

1-(pyrrolidinyl)-2,4-dinitronaphthalene

74-89-5

methylamine

A

123-75-1

pyrrolidine

B

39139-78-1

1-(Methylamino)-2,4-dinitronaphthalene

Conditions
ConditionsYield
In water at 30℃; for 1h;A n/a
B 98%
616-45-5

2-pyrrolidinon

123-75-1

pyrrolidine

Conditions
ConditionsYield
With methanesulfonic acid; ruthenium(1,1,1-tris(di(3,5-dimethylphenyl)phosphinomethyl)ethane)(η4-trimethylenemethane); hydrogen In tetrahydrofuran at 160℃; under 75007.5 Torr; for 16h; Autoclave; Schlenk technique;98%
With tris(pentafluorophenyl)borate; C21H35BrMnNO2P2; potassium tert-butylate; hydrogen In m-xylene at 150℃; under 37503.8 Torr; for 72h;81%
With borane-ammonia complex; boron trifluoride diethyl etherate; tris(pentafluorophenyl)borate In 1,2-dichloro-ethane at 60℃; for 16h;77%
110-60-1

1,4-diaminobutane

123-75-1

pyrrolidine

Conditions
ConditionsYield
HZSM-5(280) zeolite In water at 300℃; Cyclization;97%
tris(triphenylphosphine)ruthenium(II) chloride In diphenylether at 180℃; for 5h; Product distribution; other α,ω-aliphatic diamines;90%
With carbonylchloro[4,5-bis(diisopropylphosphinomethyl)acridine]hydridoruthenium(II) In 1,4-dioxane; water at 100℃; for 22h; Schlenk technique; Inert atmosphere;88%
123477-57-6

pyrrolidine-1-carboxylic acid prop-2-ynyl ester

123-75-1

pyrrolidine

Conditions
ConditionsYield
With benzyltriethylammonium tetrathiomolybdate In acetonitrile at 20℃; for 2.5h;97%
110-63-4

Butane-1,4-diol

123-75-1

pyrrolidine

Conditions
ConditionsYield
With ammonia; hydrogen; CuO/ZnO/Al2O3 at 220℃; under 26252.1 Torr;94%
With aluminum oxide; ammonia at 400℃;
With aluminum oxide; ammonia at 325℃;
5470-26-8

ethyl pyrrolidine-1-carboxylate

123-75-1

pyrrolidine

Conditions
ConditionsYield
With methyllithium; lithium bromide In tetrahydrofuran at 0℃; for 1h;94%
142653-70-1

1-(9-fluorenylmethoxycarbonyl)pyrrolidine

123-75-1

pyrrolidine

Conditions
ConditionsYield
With triethylamine; 1-butyl-3-methylimidazolium Tetrafluoroborate In neat (no solvent) at 25℃; for 0.0666667h; Green chemistry;93%
29897-82-3

N-benzylpyrrolidine

123-75-1

pyrrolidine

Conditions
ConditionsYield
With 9,10-Dicyanoanthracene In water; acetonitrile Irradiation;90%
13325-10-5

4-Aminobutanol

123-75-1

pyrrolidine

Conditions
ConditionsYield
With carbonylchloro[4,5-bis(diisopropylphosphinomethyl)acridine]hydridoruthenium(II) In 1,4-dioxane; water at 100℃; for 10h; Schlenk technique; Inert atmosphere;88%
With aluminum oxide; nitrogen at 400℃;
dihydridotetrakis(triphenylphosphine)ruthenium In neat (no solvent) at 155℃; for 24h;79 % Chromat.

C13H14BrN3O3

A

123-75-1

pyrrolidine

B

80166-90-1

5-Bromo-7-nitroindoline

Conditions
ConditionsYield
With water In 1,4-dioxane; dichloromethane at 20℃; for 12h; UV-irradiation;A 88%
B n/a
86953-79-9

tert-butyl pyrrolidine-1-carboxylate

A

123-75-1

pyrrolidine

B

115-11-7

isobutene

Conditions
ConditionsYield
With methanesulfonic acid In tetrahydrofuran at 45℃; Solvent; Temperature;A 83%
B n/a
With cyclohexene at 260.9℃; under 44 Torr; Kinetics; Further Variations:; Pressures; Temperatures;
930-55-2

N-nitrosopyrrolidine

123-75-1

pyrrolidine

Conditions
ConditionsYield
With isocyanate de chlorosulfonyle In diethyl ether for 10h; Ambient temperature;78%
67-56-1

methanol

57671-12-2

N-(4-methylphenylsulfinyl)pyrrolidine

A

123-75-1

pyrrolidine

B

672-78-6

methyl p-toluene sulfinate

Conditions
ConditionsYield
With tetraethylammonium tosylate Electrochemical reaction; reticulated vitreous carbon anode; Pt cathode;A n/a
B 75%

C20H22NO2S(1+)*BF4(1-)

A

123-75-1

pyrrolidine

B

766-92-7

[(methylthio)methyl]-benzene

C

19532-98-0

N1,N2-dimethylphthalamide

Conditions
ConditionsYield
With methylamine at 30℃; for 20h;A n/a
B 74%
C n/a
110-63-4

Butane-1,4-diol

A

123-75-1

pyrrolidine

B

767-10-2

1-butylpyrrolidine

C

93264-47-2

4-(pyrrolidin-1-yl)butan-1-ol

D

41726-75-4

1,4-di-(1-pyrrolidinyl)butane

E

109-73-9

N-butylamine

Conditions
ConditionsYield
With ammonia; hydrogen; iron RFC at 260℃; Product distribution; Mechanism; other temp. (280, 300, 310 deg C);A 71%
B 12%
C n/a
D n/a
E 9%

C17H22NO2S(1+)*BF4(1-)

A

123-75-1

pyrrolidine

B

1613-51-0

sulfure de pentamethylene

C

19532-98-0

N1,N2-dimethylphthalamide

Conditions
ConditionsYield
With methylamine at 30℃; for 20h;A n/a
B 71%
C n/a

C20H30NO2S(1+)*BF4(1-)

A

123-75-1

pyrrolidine

B

544-40-1

Dibutyl sulfide

C

19532-98-0

N1,N2-dimethylphthalamide

Conditions
ConditionsYield
With methylamine at 30℃; for 20h;A n/a
B 70%
C n/a
73722-93-7

C6H12NO(1+)*CH3O4S(1-)

A

123-75-1

pyrrolidine

B

3760-54-1

1-pyrrolidinecarboxaldehyde

C

930-55-2

N-nitrosopyrrolidine

Conditions
ConditionsYield
With sodium nitrite In waterA n/a
B 70%
C n/a
123-75-1

pyrrolidine

108-30-5

succinic acid anhydride

69338-35-8

4-oxo-4-(1-pyrrolidinyl)butanoic acid

Conditions
ConditionsYield
In acetonitrile at 20℃;100%
In chloroform for 1h; Heating;83%
With diethyl ether
Reflux;
In toluene for 2.5h; Reflux;
123-75-1

pyrrolidine

764-85-2

Nonanoyl chloride

20308-70-7

1-(pyrrolidin-1-yl)nonan-1-one

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃; for 14h; Inert atmosphere;100%
With diethyl ether; triethylamine
123-75-1

pyrrolidine

38460-95-6

undec-10-enoyl chloride

95018-99-8

1-(pyrrolidin-1-yl)undec-10-en-1-one

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃; for 14h; Inert atmosphere;100%
With triethylamine In dichloromethane at 0 - 23℃; for 14h;100%
With triethylamine In dichloromethane at 0 - 23℃; for 14h;100%
123-75-1

pyrrolidine

601-57-0

Cholest-4-en-3-one

2309-31-1

1-cholesta-3,5-dien-3-yl-pyrrolidine

Conditions
ConditionsYield
In benzene for 24h; Heating;100%
In benzene100%
93%
123-75-1

pyrrolidine

286-20-4

cyclohexane-1,2-epoxide

69420-67-3

(+/-)-trans-[2-(pyrrolidinyl)]cyclohexanol

Conditions
ConditionsYield
for 114h; Heating;100%
With lithium bromide at 20℃; for 2h;100%
With zinc(II) perchlorate hexahydrate at 80℃; for 1h;100%
123-75-1

pyrrolidine

108-94-1

cyclohexanone

1125-99-1

1-(1-Cyclohexen-1-yl)pyrrolidine

Conditions
ConditionsYield
In toluene for 18h; Molecular sieve; Dean-Stark trap; Heating / reflux;100%
With sulfuric acid In toluene Dean-Stark; Reflux;99%
With K-10 Montmorillonite clay In toluene for 2.5h; Heating;95%
123-75-1

pyrrolidine

100-00-5

4-chlorobenzonitrile

10220-22-1

1-(4-nitro-phenyl)-pyrrolidine

Conditions
ConditionsYield
In tetrahydrofuran at 50℃; under 4500360 Torr; for 20h;100%
In tetrahydrofuran at 50℃; under 6000 Torr; for 2h; Product distribution; other pressure;100%
at 108℃; for 2h; Neat (no solvent);98%
123-75-1

pyrrolidine

292638-85-8

acrylic acid methyl ester

22041-21-0

methyl 3-(pyrrolidin-1-yl)propanoate

Conditions
ConditionsYield
With zirconium(IV) chloride In dichloromethane at 20℃; for 0.75h; Michael addition;100%
With silica-supported aluminum chloride at 60℃; for 2h; Michael addition; Neat (no solvent);100%
In dichloromethane at 0 - 20℃; for 2h;100%
123-75-1

pyrrolidine

79-04-9

chloroacetyl chloride

20266-00-6

chloroacetic acid pyrrolidide

Conditions
ConditionsYield
In acetone at 20℃;100%
In tetrahydrofuran at 0 - 20℃; for 3.5h;99%
In tetrahydrofuran at 20℃; for 12h; Acylation;98%
123-75-1

pyrrolidine

103-80-0

phenylacetyl chloride

3389-53-5

phenylacetylpyrrolidine

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0 - 20℃;100%
With triethylamine In dichloromethane at 20℃; for 14h; Inert atmosphere;100%
With triethylamine In dichloromethane at 20℃;92%
123-75-1

pyrrolidine

3760-55-2

1-nitropyrrolidine

Conditions
ConditionsYield
With 2-(trifluoromethyl)-2-propyl nitrate at 50℃; for 168h;100%
With nitronium trifluoromethanesulfonate In dichloromethane at -20℃; for 1h;43%
With tetrachloromethane; dinitrogen pentoxide
With butyl nitrate; ethylmagnesium bromide 1.) benzene, 15 min, 2.) benzene, 0.5 h; Yield given. Multistep reaction;
123-75-1

pyrrolidine

285-67-6

Cyclopentene oxide

32635-39-5

(+/-)-trans-(1-pyrrolidinyl)cyclopentan-2-ol

Conditions
ConditionsYield
bismuth(lll) trifluoromethanesulfonate at 160℃; for 0.25h; microwave irradiation;100%
With triethylaluminum 1.) toluene, CH2Cl2, 25-30 deg C, 30 min, 2.) room temperature; Yield given. Multistep reaction;
In water
With potassium carbonate
In ethanol at 80℃; for 18h; Inert atmosphere;
123-75-1

pyrrolidine

96-48-0

4-butanolide

73200-24-5

4-hydroxy-1-(pyrrolidin-1-yl)butan-1-one

Conditions
ConditionsYield
With triethylamine Inert atmosphere; Reflux;100%
With triethylamine for 16h; Reflux;94%
In benzene for 3h; Heating;90%
123-75-1

pyrrolidine

542-28-9

3,4,5,6-tetrahydro-2H-pyran-2-one

73200-35-8

5-hydroxy-1-(pyrrolidin-1-yl)pentan-1-one

Conditions
ConditionsYield
With triethylamine Inert atmosphere; Reflux;100%
In benzene82%
123-75-1

pyrrolidine

103-82-2

phenylacetic acid

3389-53-5

phenylacetylpyrrolidine

Conditions
ConditionsYield
Stage #1: phenylacetic acid With 4-iodofuran-3-yl-boronic acid In dichloromethane for 0.166667h; Molecular sieve 4Å;
Stage #2: pyrrolidine In dichloromethane at 25℃; for 6h; Product distribution / selectivity;
100%
With 4 A molecular sieve at 150℃; for 2h;98%
With tetramethylorthosilicate In toluene at 110℃; for 1h; Inert atmosphere;98%
123-75-1

pyrrolidine

636-98-6

p-nitrobenzene iodide

10220-22-1

1-(4-nitro-phenyl)-pyrrolidine

Conditions
ConditionsYield
In tetrahydrofuran at 50℃; under 9000720 Torr; for 20h;100%
With copper(l) iodide; 1-(5,6,7,8-tetrahydroquinolin-8-yl)ethan-1-one; caesium carbonate In N,N-dimethyl-formamide at 25℃; for 24h; Ullmann condensation; Inert atmosphere;95%
With copper(l) iodide In N,N-dimethyl acetamide at 130℃; for 24h;95%
123-75-1

pyrrolidine

72553-83-4

1-Chlor-4-phenyl-pyridazino<4,5-d>pyridazin

83490-50-0

1-Pyrrolidino-4-phenyl-pyridazino<4,5-d>pyridazin

Conditions
ConditionsYield
for 3h; Heating;100%
123-75-1

pyrrolidine

74151-83-0

6'-chloro-1,3,1',3'-tetramethyl-3H,1'H-[4,5']bipyrimidinyl-2,6,2',4'-tetraone

1,3,1',3'-Tetramethyl-6-pyrrolidin-1-yl-1H,1'H-[5,5']bipyrimidinyl-2,4,2',4'-tetraone

Conditions
ConditionsYield
100%
123-75-1

pyrrolidine

2033-24-1

cycl-isopropylidene malonate

96-17-3, 57456-98-1

2-Methylbutyraldehyde

2,2-Dimethyl-5-(2-methyl-1-pyrrolidin-1-yl-butyl)-[1,3]dioxane-4,6-dione

Conditions
ConditionsYield
In diethyl ether for 0.166667h;100%
123-75-1

pyrrolidine

2033-24-1

cycl-isopropylidene malonate

123-05-7

d,l-2-ethylhexanal

93498-12-5

5-(2-Ethyl-1-pyrrolidin-1-yl-hexyl)-2,2-dimethyl-[1,3]dioxane-4,6-dione

Conditions
ConditionsYield
In diethyl ether for 0.166667h;100%
123-75-1

pyrrolidine

2033-24-1

cycl-isopropylidene malonate

100-52-7

benzaldehyde

93498-11-4

2,2-Dimethyl-5-(phenyl-pyrrolidin-1-yl-methyl)-[1,3]dioxane-4,6-dione

Conditions
ConditionsYield
In diethyl ether for 0.166667h;100%
123-75-1

pyrrolidine

2033-24-1

cycl-isopropylidene malonate

123-38-6

propionaldehyde

93498-07-8

2,2-Dimethyl-5-(1-pyrrolidin-1-yl-propyl)-[1,3]dioxane-4,6-dione

Conditions
ConditionsYield
In diethyl ether for 0.166667h;100%
123-75-1

pyrrolidine

2033-24-1

cycl-isopropylidene malonate

123-72-8

butyraldehyde

93498-08-9

2,2-Dimethyl-5-(1-pyrrolidin-1-yl-butyl)-[1,3]dioxane-4,6-dione

Conditions
ConditionsYield
In diethyl ether for 0.166667h;100%
123-75-1

pyrrolidine

2033-24-1

cycl-isopropylidene malonate

78-84-2

isobutyraldehyde

93498-09-0

2,2-Dimethyl-5-(2-methyl-1-pyrrolidin-1-yl-propyl)-[1,3]dioxane-4,6-dione

Conditions
ConditionsYield
In diethyl ether for 0.166667h;100%
123-75-1

pyrrolidine

50-00-0

formaldehyd

142238-04-8

1-acetyl-3-(2-propynyl)-2-imidazolidone

142237-98-7

1-Acetyl-3-(4-pyrrolidin-1-yl-but-2-ynyl)-imidazolidin-2-one

Conditions
ConditionsYield
With acetic acid; copper(l) chloride In 1,4-dioxane at 50℃; for 4h;100%
123-75-1

pyrrolidine

1008-76-0

4,5-dihydro-5-phenyl-2(3H)-furanone

99802-88-7

4-hydroxy-4-phenyl-1-(pyrrolidine-1-yl)butan-1-one

Conditions
ConditionsYield
With triethylamine Reflux; Inert atmosphere;100%
With triethylamine for 72h; Schlenk technique; Reflux;97%
In water for 4h; Heating;90%
123-75-1

pyrrolidine

5911-65-9

5,6,9,10,11,11a-Hexahydro-2,3-dimethoxy-8,10-dioxo-8H-benzoquinolizine

85222-89-5

5,6,11,11a-Tetrahydro-2,3-dimethoxy-8-oxo-10-(1-pyrrolidinyl)-8H-benzoquinolizine

Conditions
ConditionsYield
In benzene for 1h; Heating;100%
123-75-1

pyrrolidine

18410-00-9

7α,11β-eudesm-4-en-12,6α-olide

(S)-2-((1S,2S,4aR)-1-Hydroxy-4a,8-dimethyl-1,2,3,4,4a,5,6,7-octahydro-naphthalen-2-yl)-1-pyrrolidin-1-yl-propan-1-one

Conditions
ConditionsYield
In benzene for 30h; Ambient temperature;100%
123-75-1

pyrrolidine

(S)-2-((1S,2S,4aR)-1-Hydroxy-4a,8-dimethyl-1,2,3,4,4a,5,6,8a-octahydro-naphthalen-2-yl)-1-pyrrolidin-1-yl-propan-1-one

Conditions
ConditionsYield
In benzene for 18h; Ambient temperature;100%
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    123-75-1

    Tetrahydro pyrrole

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  • Pyrrolidine CAS 123-75-1 C4H10N

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    Pyrrolidine CAS 123-75-1 C4H10N

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    四氢吡咯,又称四氢化吡咯,CAS#123-75-1,分子式C4H9N,结构式,分子量71.12,无色透明液体,沸点86~88℃ (常压),是一种重要的化工、医药中间体,广泛应用于医药、食品、农药、日用化学品、涂料、纺织、印染、造纸、感光材料、高分子材料、脱硫剂、沸石模板物质等领域。 产品执行标准:Q/PMQ008-2015;产品质量规格如下表: 项 目 指 标 高纯

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    123-75-1

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    Tetrahydro pyrrole /Tetrahydropyrrole /Pyrrolidine

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  • Pyrrolidine

  • Casno:

    123-75-1

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    123-75-1

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    Tetrahydro pyrrole Basic information Product Name: Tetrahydro pyrrole Synonyms: Azolidine;Butylenimine;perhydroazole;Perhydropyrrole;Prolamine;Pyrrole, tetrahydro-;Pyrrolidene;Pyrrolidin CAS: 123-75-1 MF: C4H9N MW: 71.12 EINECS: 204-648-7 P

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Consensus Reports

Reported in EPA TSCA Inventory.

Standards and Recommendations

DOT Classification:  3;
Label: Flammable Liquid

Specification

The Pyrrolidine with CAS registry number of 123-75-1 is also known as Tetrahydropyrrole. The IUPAC name and product name are the same. It belongs to product categories of Imidazoles, Pyrroles, Pyrazoles, Pyrrolidines; Flavor. Its EINECS registry number is 204-648-7. In addition, the formula is C4H9N and the molecular weight is 71.12. This chemical is a colourless to pale yellow liquid and should be sealed in dark place.

Physical properties about Pyrrolidine are: (1)ACD/LogP: 0.09; (2)ACD/BCF (pH 5.5): 1; (3)ACD/BCF (pH 7.4): 1; (4)ACD/KOC (pH 5.5): 1; (5)ACD/KOC (pH 7.4): 1; (6)#H bond acceptors: 1; (7)#H bond donors: 1; (8)Index of Refraction: 1.428; (9)Molar Refractivity: 21.795 cm3; (10)Molar Volume: 84.749 cm3; (11)Surface Tension: 26.891 dyne/cm; (12)Density: 0.839 g/cm3; (13)Flash Point: 2.778 °C; (14)Enthalpy of Vaporization: 33.01 kJ/mol; (15)Boiling Point: 89.451 °C at 760 mmHg; (16)Vapour Pressure: 58.582 mmHg at 25 °C.

Preparation of Pyrrolidine: it is prepared by reaction of maleic anhydride. Product is obtained by hydrogenation and amination.

Pyrrolidine is prepared by reaction of maleic anhydride.

Uses of Pyrrolidine: it is used to produce 1-prop-2-ynyl-pyrrolidine by reaction with 3-bromo-propyne. The reaction occurs with reagents KOH, alumina and solvent aliquat 336 at 20 °C. The yield is about 55%. Besides, it is also used as pharmaceutical raw materials, organic synthesis and special organic solvent.

Pyrrolidine is used to produce 1-prop-2-ynyl-pyrrolidine by reaction with 3-bromo-propyne.

When you are using this chemical, please be cautious about it. As a chemical, it is harmful by inhalation, in contact with skin and if swallowed. It is highly flammable and may cause severe burns. During using it, wear suitable protective clothing, gloves and eye/face protection. Take precautionary measures against static discharges and keep away from sources of ignition. If contact with eyes accidently, rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
1. Canonical SMILES: C1CCNC1
2. InChI: InChI=1S/C4H9N/c1-2-4-5-3-1/h5H,1-4H2
3. InChIKey: RWRDLPDLKQPQOW-UHFFFAOYSA-N

The toxicity data is as follows:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LDLo oral 250mg/kg (250mg/kg)   "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 104, 1982.
mammal (species unspecified) LD50 oral 250mg/kg (250mg/kg)   Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 39(4), Pg. 86, 1974.
mouse LC50 inhalation 1300mg/m3/2H (1300mg/m3) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: EXCITEMENT

VASCULAR: OTHER CHANGES
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 18(2), Pg. 29, 1974.
mouse LD50 intraperitoneal 420mg/kg (420mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 88, Pg. 82, 1946.
mouse LD50 intravenous 56mg/kg (56mg/kg)   U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#06769,
mouse LD50 oral 450mg/kg (450mg/kg)   Bollettino Chimico Farmaceutico. Vol. 103, Pg. 414, 1964.
rabbit LDLo oral 250mg/kg (250mg/kg)   "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 104, 1982.
rat LD50 oral 300mg/kg (300mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: EXCITEMENT

VASCULAR: OTHER CHANGES
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 18(2), Pg. 29, 1974.