Hot Products

Basic Information

Post buying leads

Suppliers

Cas Database

Name	L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid	EINECS	-0
CAS No.	74163-81-8	Density	1.225 g/cm³
PSA	49.33000	LogP	1.11430
Solubility	N/A	Melting Point	300 °C
Formula	C₁₀H₁₁NO₂	Boiling Point	372 °C at 760 mmHg
Molecular Weight	177.203	Flash Point	178.8 °C
Transport Information	N/A	Appearance	white to light yellow crystal powder
Safety	26-36/37/39	Risk Codes	36/37/38
Molecular Structure		Hazard Symbols	Xi
Synonyms	3-Isoquinolinecarboxylicacid, 1,2,3,4-tetrahydro-, (S)-;(-)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylicacid;(3S)-1,2,3,4-Tetrahydro-3-isoquinolinecarboxylic acid;(S)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid;	Article Data	35

L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid Synthetic route

: 50-00-0
formaldehyd

: 63-91-2
L-phenylalanine

: 74163-81-8
L-Tic-OH

Conditions

Conditions	Yield
With hydrogenchloride In water at 90℃; for 12h; Pictet-Spengler Synthesis;	98%
With hydrogenchloride In water at 90℃; for 12h;	98%
With hydrogenchloride at 85℃; for 9h; Pictet-Spengler condensation;	95%

: 143767-56-0
(-)-menthyl (S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylate

: 74163-81-8
L-Tic-OH

Conditions

Conditions	Yield
With sodium hydroxide In methanol for 6h; Ambient temperature;	94%

: 77497-96-2
(S)-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid, phenylmethylester

: 74163-81-8
L-Tic-OH

Conditions

Conditions	Yield
With sodium hydroxide In water for 15h; Ambient temperature;	81%
With hydrogen; palladium on activated charcoal In ethanol; water; acetic acid for 4h; Ambient temperature;	75.4%

: 367952-43-0
(10aS)-3,3-Bis(trifluoromethyl)-1-oxo-(1,2,3,4-tetrahydroisoquinolino)[2,3-c]oxazolidine

: 74163-81-8
L-Tic-OH

Conditions

Conditions	Yield
With water In isopropyl alcohol at 20℃;	72%

: 67123-97-1
(R,S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid

: 74163-81-8
L-Tic-OH

Conditions

Conditions	Yield
With ammonium hydroxide; borane-ammonia complex; recombinant Escherichia coli BL21 (DE3) cells expressed D-amino acid oxidase from Fusarium solani M-0718 In water at 30℃; pH=8; Resolution of racemate; Enzymatic reaction; enantioselective reaction;	68%

: 123053-49-6
(3R,10bS)-3-tert-Butyl-2-methyl-2,3,6,10b-tetrahydro-5H-imidazo[5,1-a]isoquinolin-1-one

: 74163-81-8
L-Tic-OH

Conditions

Conditions	Yield
With hydrogenchloride; Dowex 50-WX8; acetic acid In water; toluene at 103℃; for 126h;	67%

: 307304-56-9
(3'S,4R,5S)-1,5-dimethyl-4-phenyl-3-(1',2',3',4'-tetrahydro-3'-isoquinolinylcarbonyl)-2-imidazolidinone

A: 74163-81-8
L-Tic-OH

B: 103733-65-9
(3R)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid

Conditions

Conditions	Yield
With water for 12h; Hydrolysis; epimerization; Heating; Title compound not separated from byproducts.;

: 15912-55-7, 41234-43-9, 55857-63-1
ethyl 1,2,3,4-tetrahydroisoquinoline-3-(S)-carboxylate

: 74163-81-8
L-Tic-OH

Conditions

Conditions	Yield
With chicken liver acetone; water pH=7.5;

: 57060-86-3
1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid

: 74163-81-8
L-Tic-OH

Conditions

Conditions	Yield
With chicken liver acetone; water for 2h; pH=7.5;

: (+/-)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid butyl ester

: 74163-81-8
L-Tic-OH

Conditions

Conditions	Yield
With chicken liver acetone; water pH=7.5;

L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid Chemical Properties

IUPAC Name: (3S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid
Synonyms of L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid (CAS NO.74163-81-8): 3-Isoquinolinecarboxylicacid, 1,2,3,4-tetrahydro-, (S)- ; (3S)-1,2,3,4-Tetrahydro-3-isoquinolinecarboxylic acid ; S-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid
CAS NO: 74163-81-8
Molecular Formula: C₁₀H₁₁NO₂
Molecular Weight: 177.20
Molecular Structure:
H bond acceptors: 3
H bond donors: 2
Freely Rotating Bonds: 1
Polar Surface Area: 29.54 Å²
Index of Refraction: 1.576
Molar Refractivity: 47.88 cm³
Molar Volume: 144.5 cm³
Surface Tension: 48.2 dyne/cm
Density: 1.225 g/cm³
Flash Point: 178.8 °C
Enthalpy of Vaporization: 65.31 kJ/mol
Boiling Point: 372 °C at 760 mmHg
Vapour Pressure: 3.41E-06 mmHg at 25°C
Melting point: 300 °C
Alpha: -157.4 º (24°C)
Storage temp: Store at 0-5°C
Appearance: white to light yellow crystal powder
Product Categories of L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid (CAS NO.74163-81-8): Amino Acids;Carboxylic Acids;Quinolines, Isoquinolines & Quinoxalines;chiral;(intermediate of quinapril);Carboxylic Acids;Quinolines, Isoquinolines & Quinoxalines;IsoquinolinesPeptide Synthesis;Chiral Building Blocks;Heterocyclic Building Blocks;Others;Unnatural Amino Acid Derivatives;Peptide Synthesis;a-amino

L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid Safety Profile

Safety Information about L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid (CAS NO.74163-81-8):
Hazard Codes: Irritant Xi
Risk Statements: 36/37/38
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36/37/39
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.
WGK Germany: 3

L-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid Specification

General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or chemical foam
Handling: Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes.
Storage: Store in a cool, dry place. Store in a tightly closed container.

Post a RFQ

Cas No.:

Product Name:

Quantity:

Email:

Company name:

Valid Period:

Detailed Requirements:

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

What can I do for you?
Get Best Price

Get Best Price for 74163-81-8