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EINECS 205-702-2
CAS No. 147-85-3 Density 1.186 g/cm3
Solubility soluble Melting Point 228 °C (dec.)(lit.)
Formula C5H9NO2 Boiling Point 252.2 °C at 760 mmHg
Molecular Weight 115.13 Flash Point 106.3 °C
Transport Information Appearance White crystalline powder
Safety 24/25-36/37/39-26 Risk Codes 36/37/38-22
Molecular Structure Molecular Structure of 147-85-3 (L-Proline) Hazard Symbols HarmfulXn,IrritantXi

L-Prolin;(S)-Pyrrolidine-2-carboxylic acid;L-Pyrrolidine-2-carboxylic acid;(-)-Proline (S)-2-Carboxypyrrolidine;CCCu;2-Pyrralidinecarboxylic acid, (S)-;2-Pyrrolidinecarboxylic acid, (S)-;(-)-2-Pyrrolidinecarboxylic acid;L-(-)-Proline;PRO;(2S)-2,3,4,5-tetrahydropyrrole-2-carboxylate;(S)-Proline;(-)-(S)-Proline;H-Pro-OH~(S)-Pyrrolidine-2-carboxylic acid;


L-Proline History

Hermann Emil Fischer discovered proline between 1899 and 1908.

L-Proline Specification

1. Introduction of L-Proline

L-Proline, with the chemical name of 2-Pyrrolidinecarboxylic acid, is one kind of white crystalline powder. For being soluble in the water, L-Proline is incompatible with strong oxidizing agents, and it will belong to the Product Categories which include Food & Feed ADDITIVES; Amino Acid Derivatives; Proline [Pro, P]; Amino Acids; Amino Acids and Derivatives; alpha-Amino Acids; Biochemistry; Nutritional Supplements; L-Amino Acids; Amino Acids.

2. Properties of L-Proline

L-Proline has the following properties datas: (1)Index of Refraction: 1.487; (2)Molar Refractivity: 27.9 cm3; (3)Molar Volume: 96.9 cm3; (4)Polarizability: 11.06×10-24 cm3; (5)Surface Tension: 43.4 dyne/cm; (6)Density: 1.186 g/cm3; (7)Flash Point: 106.3 °C; (8)Enthalpy of Vaporization: 53.9 kJ/mol; (9)Melting Point: 228 °C (dec.)(lit.); (10)Boiling Point: 252.2 °C at 760 mmHg; (11)Vapour Pressure: 0.00615 mmHg at 25°C.

3. Structure Descriptors of L-Proline

You could convert the following datas into the molecular structure:
(1)InChI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1
(3)Smiles: C([C@@H]1CCCN1)(O)=O

4. Safety Information of L-Proline

Hazard Codes: IrritantXi,HarmfulXn
Risk Statements: 36/37/38-22
36/37/38: Irritating to eyes, respiratory system and skin 
22: Do not breathe dust  
Safety Statements: 24/25-36/37/39-26
24/25: Avoid contact with skin and eyes 
36/37/39: Wear suitable protective clothing, gloves and eye/face protection 
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 
WGK Germany: 3
RTECS: TW3584000
F: 3-10: Hygroscopic. Keep under argon.
HS Code: 29339990

And following are some specific cases and their according measures:
Ingestion: If victim is conscious and alert, give 2-4 cupfuls of milk or water. Get medical aid immediately.
Inhalation: Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Skin: Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Get medical aid if irritation develops or persists.
Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

5. Usage of L-Proline

L-Proline can be used as nutritional supplements, flavor agent, and aroma.It can also be used as pharmaceutical raw materials and food additives. It is one of the important amino acids of human proteins. It is also an important raw material for amino acid infusion. L-proline has been widely used in food and pharmaceutical industry . It is an osmoprotectant and therefore is used in many pharmaceutical, biotechnological applications.

6. Handling and Storage of L-Proline

Storage: Store in a cool, dry, well-ventilated area away from incompatible substances.
Handling: Wash thoroughly after handling. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with skin and eyes. Keep container tightly closed. Avoid ingestion and inhalation.

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