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Mebendazole

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Name

Mebendazole

EINECS 250-635-4
CAS No. 31431-39-7 Density 1.388 g/cm3
Solubility Melting Point 288.5 °C
Formula C16H13N3O3 Boiling Point
Molecular Weight 295.30 Flash Point
Transport Information UN 2811 Appearance white to yellowish powder
Safety 36 Risk Codes 22
Molecular Structure Molecular Structure of 31431-39-7 (Mebendazole) Hazard Symbols HarmfulXn
Synonyms

Methyl 5-benzoyl-2-benzimidazolecarbamate;2-Benzimidazolecarbamic acid, 5-benzoyl-, methyl ester;Sufil;R 17635;Equivurm Plus;MBDZ;Methyl 5-benzoyl benzimidazole-2-carbamate;Versid;(5-Benzoyl-1H-benzimidazol-2-yl)carbamic acid methyl ester;Mebex;Verpanyl;Mebendazole (JAN/USP);2-Benzimidazolecarbamic acid, 5-benzoyl-, methyl ester (8CI);Mebutar;5-Benzoyl-2-benzimidazolecarbamic acid methyl ester;Telmin;Vermox (TN);R 17,635;Bantenol;Telluryl compoundsTelmin;Vermox;R 17, 635;Lomper;Pantelmin;Methyl 5-benzoyl-2-benzimidazolylcarbamate;

 

Mebendazole Chemical Properties

Molecular Structure of Mebendazole (CAS NO.31431-39-7):

IUPAC Name: methyl N-(6-Benzoyl-1H-benzimidazol-2-yl)carbamate
Canonical SMILES: COC(=O)NC1=NC2=C(N1)C=C(C=C2)C(=O)C3=CC=CC=C3
InChI: InChI=1S/C16H13N3O3/c1-22-16(21)19-15-17-12-8-7-11(9-13(12)18-15)14(20)10-5-3-2-4-6-10/h2-9H,1H3,(H2,17,18,19,21)
InChIKey: OPXLLQIJSORQAM-UHFFFAOYSA-N
Molecular Formula: C16H13N3O3
Molar mass: 295.2927 g/mol
Index of Refraction: 1.702
Molar Refractivity: 82.43 cm3
Molar Volume: 212.6 cm3
Surface Tension: 66.7 dyne/cm
Density: 1.388 g/cm3
Melting point: 288.5 °C
storage temp: 0-6 °C
Water solubility: insoluble
Appearance: White Amorphous Powder
Product Categories: Intermediates & Fine Chemicals; Miscellaneous Natural Products; Miscellaneous Enzyme; Pharmaceuticals

Mebendazole Uses

 Mebendazole (CAS NO.31431-39-7) is used to treat infestations by worms including pinworms, roundworms, tapeworms, hookworms, and whipworms.

Mebendazole Production

Take o-dichlorobenzene and benzoyl chloride as raw materials,the product can be derived by condensation, amination, cyclization.

Mebendazole Toxicity Data With Reference

cat LD50 oral > 640mg/kg (640mg/kg)   Toxicology and Applied Pharmacology. Vol. 24, Pg. 371, 1973.
chicken LD50 unreported > 40mg/kg (40mg/kg)   United States Patent Document. Vol. #3657267,
dog LD intramuscular > 2gm/kg (2000mg/kg)   Drugs in Japan Vol. -, Pg. 1207, 1990.
dog LD50 oral 1280mg/kg (1280mg/kg)   Drugs in Japan Vol. -, Pg. 1207, 1990.
domestic animals - goat/sheep LD50 oral > 80mg/kg (80mg/kg)   United States Patent Document. Vol. #3657267,
guinea pig LD50 oral > 1280mg/kg (1280mg/kg)   Toxicology and Applied Pharmacology. Vol. 24, Pg. 371, 1973.
mouse LD50 intraperitoneal 712mg/kg (712mg/kg)   Meditsinskaya Parazitologiya i Parazitarnye Bolezni. Medical Parasitology and Parasitic Diseases. Vol. 48(4), Pg. 29, 1979.
mouse LD50 oral 620mg/kg (620mg/kg)   Meditsinskaya Parazitologiya i Parazitarnye Bolezni. Medical Parasitology and Parasitic Diseases. Vol. 47(6), Pg. 48, 1978.
rabbit LD50 oral > 640mg/kg (640mg/kg)   Toxicology and Applied Pharmacology. Vol. 24, Pg. 371, 1973.
rat LD50 intramuscular 350mg/kg (350mg/kg)   Drugs in Japan Vol. -, Pg. 1207, 1990.
rat LD50 oral 714mg/kg (714mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 19, Pg. 735, 1988.

Mebendazole Consensus Reports

EPA Genetic Toxicology Program.

Mebendazole Safety Profile

Moderately toxic by ingestion and intraperitoneal routes. Human mutation data reported. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx.
Safety Information of Mebendazole (CAS NO.31431-39-7):
Hazard Codes: Xn
Risk Statements:
22:  Harmful if swallowed 
Safety Statements:
36:  Wear suitable protective clothing
RIDADR: UN 2811
WGK Germany: 3
RTECS: EY8600000

Mebendazole Specification

 Mebendazole (CAS NO.31431-39-7), its Synonyms are (5-Benzoyl-1H-benzimidazol-2-yl)-carbamic acid methyl ester ; 2-Benzimidazolecarbamic acid, 5-benzoyl-, methyl ester ; 5-Benzoyl-2-benzimidazolecarbamic acid methyl ester ; Bantenol ; Besantin ; Mebendazolum ; Methyl 5-benzoyl-2-benzimidazolecarbamate ; Methyl 5-benzoyl-2-benzimidazolylcarbamate ; Methyl N-(5-benzoyl-2-benzimidazolyl)carbamate ; N-(Benzoyl-5, benzimidazolyl)-2, carbamate de methyle ; N-2 (5-Benzoyl-benzimidazole) carbamate de methyle .

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