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1982-37-2

Basic Information
CAS No.: 1982-37-2
Name: 10-((1-METHYL-3-PYRROLIDINYL)METHYL)-PHENOTHIAZINE
Molecular Structure:
Molecular Structure of 1982-37-2 (10-((1-METHYL-3-PYRROLIDINYL)METHYL)-PHENOTHIAZINE)
Formula: C18H20 N2 S
Molecular Weight: 296.46
Synonyms: Phenothiazine,10-[(1-methyl-3-pyrrolidinyl)methyl]- (6CI,7CI,8CI);10-((1-Methyl-3-pyrrolidinyl)methyl)-10H-phenothiazine;10-[(1-Methyl-3-pyrrolidinyl)methyl]phenothiazine; MJ 5022; Methdilazine
EINECS: 217-841-6
Density: 1.185 g/cm3
Melting Point: 87-88℃
Boiling Point: 430.4 ºC at 760 mmHg
Flash Point: 214.1 ºC
Solubility:
Appearance:
Hazard Symbols:
Risk Codes:
Safety: Poison by ingestion and intraperitoneal routes. Human systemic effects by ingestion: somnolence, dyspnea and gastrointestinal changes. When heated to decomposition it emits very toxic fumes of SOx and NOx.
Transport Information:
PSA: 31.78000
LogP: 4.24390
Synthetic route
58689-43-3

3-chloromethyl-1-methylpyrrolidine

92-84-2

10H-phenothiazine

1982-37-2

methdilazine

Conditions
ConditionsYield
With sodium amide
92-84-2

10H-phenothiazine

(+-)-3-chloromethyl-1-methyl-pyrrolidine

(+-)-3-chloromethyl-1-methyl-pyrrolidine

1982-37-2

methdilazine

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    1982-37-2

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  • 10-[(1-methylpyrrolidin-3-yl)methyl]phenothiazine

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    1982-37-2

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  • 10-[(1-methylpyrrolidin-3-yl)methyl]phenothiazine/ 1982-37-2

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    1982-37-2

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    1982-37-2

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Chemistry

IUPAC Name: 10-((1-Methyl-3-pyrrolidinyl)methyl)-10H-phenothiazine
The MF of 10-((1-Methyl-3-pyrrolidinyl)methyl)-10H-phenothiazine (1982-37-2) is C18H20N2S.

                                      
The MW of 10-((1-Methyl-3-pyrrolidinyl)methyl)-10H-phenothiazine (1982-37-2) is 296.4298.
Synonyms of 10-((1-Methyl-3-pyrrolidinyl)methyl)-10H-phenothiazine (1982-37-2): Methdilazine (200 mg) ; 10-((1-Methyl-3-pyrrolidinyl)methyl)-phenothiazin ; 10-((1-Methyl-3-pyrrolidinyl)methyl)-phenothiazine ; 10-[(1-Methyl-3-pyrrolidinyl)methyl]-10h-phenothiazine ; 10-[(1-Methyl-3-pyrrolidinyl)methyl]phenothiazine ; 10H-Phenothiazine,10-[(1-methyl-3-pyrrolidinyl)methyl]- ; Dilosyn ; Disyncram
Index of Refraction: 1.642 
Form: Crystals
EINECS: 217-841-6 
Density: 1.185 g/ml 
Flash Point: 214.1 °C
Boiling Point: 430.4 °C
Sensitive: sensitive to light

Uses

   10-((1-Methyl-3-pyrrolidinyl)methyl)-10H-phenothiazine (1982-37-2) is used as antihistamines.

Toxicity Data With Reference

1.    

orl-hmn TDLo:4 mg/kg:CNS,GIT,PUL

    34ZIAG    Toxicology of Drugs and Chemicals ,Deichmann, W.B.,New York, NY.: Academic Press, Inc.,1969,379.
2.    

orl-rat LD50:162 mg/kg

    TXAPA9    Toxicology and Applied Pharmacology. 18 (1971),185.
3.    

orl-mus LD50:225 mg/kg

    27ZQAG    Psychotropic Drugs and Related Compounds E. Usdin andD.H. Efron,2nd ed.,Washington, DC.: 1972,29.
4.    

ipr-mus LD50:183 mg/kg

    27ZQAG    Psychotropic Drugs and Related Compounds E. Usdin andD.H. Efron,2nd ed.,Washington, DC.: 1972,29.
5.    

orl-gpg LD50:263 mg/kg

    27ZQAG    Psychotropic Drugs and Related Compounds E. Usdin andD.H. Efron,2nd ed.,Washington, DC.: 1972,29.

Safety Profile

Poison by ingestion and intraperitoneal routes. Human systemic effects by ingestion: somnolence, dyspnea and gastrointestinal changes. When heated to decomposition it emits very toxic fumes of SOx and NOx.