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Mirtazapine

  • Name Mirtazapine
  • EINECS288-060-6
  • CAS No. 61337-67-5
  • Density1.22 g/cm3
  • PSA19.37000
  • LogP2.48180
  • SolubilityDMSO: 8 mg/mL
  • Melting Point114-116 °C
  • FormulaC17H19N3
  • Boiling Point432.4 °C at 760 mmHg
  • Molecular Weight265.358
  • Flash Point215.3 °C
  • Transport InformationN/A
  • Appearancewhite crystalline solid
  • Safety22-24/25
  • Risk Codes11-23/24/25-39/23/24/25
  • Molecular Structure
    Molecular Structure of 61337-67-5 (Mirtazapine)
  • Hazard SymbolsF,T
  • SynonymsF,T
  • Article Data40

Mirtazapine Chemical Properties


IUPAC Name: (±)-1,2,3,4,10,14B-Hexahydro-2-[11C]methylpyrazino(2,1-a)pyrido(2,3-c)(2)benzazepine
Molecular Formula: C17H19N3
Molecular Weight: 265.35 g/mol
Canonical SMILES: N12[C@@H](c3c(cccc3)Cc3c1nccc3)C[N@@](C)CC2
InChI: InChI=1/C17H19N3/c1-19-9-10-20-16(12-19)15-7-3-2-5-13(15)11-14-6-4-8-18-17(14)20/h2-8,16H,9-12H2,1H3
Product Categories: Intermediates & Fine Chemicals; Pharmaceuticals; Serotonin
Classification Code: Adrenergic Agents; Adrenergic Antagonists; Adrenergic alpha-antagonists; Antidepressant; Antidepressive Agents; Antidepressive agents, tricyclic; Central Nervous System Agents; Histamine Agents; Histamine Antagonists; Histamine H1 antagonists; Neurotransmitter Agents; Psychotropic Drugs
Melting Point: 114-116 °C
solubility  DMSO: 8 mg/mL, soluble
Index of Refraction: 1.667 
Molar Refractivity: 80.68 cm3 
Molar Volume: 216.5 cm3 
Polarizability: 31.98×10-24 cm3 
Surface Tension: 59.4 dyne/cm 
Density: 1.22 g/cm
Flash Point: 215.3 °C 
Enthalpy of Vaporization: 68.82 kJ/mol 
Boiling Point: 432.4 °C at 760 mmHg 
Vapour Pressure of Mirtazapine (CAS NO.61337-67-5): 1.11E-07 mmHg at 25 °C

Mirtazapine History

 Mirtazapine was introduced by Organon International in the United States in 1990 for the treatment of depression. It quickly spread throughout most of the rest of the world as well and became a widely used antidepressant, particularly for those desiring to gain weight.

Mirtazapine Uses

 Mirtazapine (CAS NO.61337-67-5) is a tetracyclic antidepressant (TeCA) used primarily in the treatment of depression. It is also sometimes used as an anxiolytic, hypnotic, antiemetic, appetite stimulant, and antihistamine, among other indications. Along with its close analogues mianserin and setiptiline, mirtazapine is one of the few noradrenergic and specific serotonergic antidepressants (NaSSAs).

Mirtazapine Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man TDLo oral 1071ug/kg/I (1.071mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"
Journal of Clinical Psychiatry. Vol. 59, Pg. 233, 1998.

Mirtazapine Safety Profile

Human systemic effects. When heated to decomposition it emits toxic vapors of NOx.
Safety Statements: 22-24/25 
S22:Do not breathe dust. 
S24/25:Avoid contact with skin and eyes.
WGK Germany of Mirtazapine (CAS NO.61337-67-5): 3

Mirtazapine Specification

 Mirtazapine (CAS NO.61337-67-5), its Synonyms are 1,2,3,4,10,14b-Hexahydro-2-methylpyrazino(2,1-a)pyrido(2,3-c)benzazepine ; Mirtazapina ; Pyrazino(2,1-a)pyrido(2,3-c)(2)benzazepine, 1,2,3,4,10,14b-hexahydro-2-methyl- ; Remeron ; Remeron SolTab . It is white crystalline solid.

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