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Mupirocin

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Name

Mupirocin

EINECS 231-791-2
CAS No. 12650-69-0 Density 1.183 g/cm3
PSA 146.05000 LogP 2.59250
Solubility soluble in water: 12 mg/mL Melting Point 77-78 ºC
Formula C26H44O9 Boiling Point 672.3 ºC at 760 mmHg
Molecular Weight 500.63 Flash Point 216.5 ºC
Transport Information N/A Appearance white crystalline solid
Safety Risk Codes N/A
Molecular Structure Molecular Structure of 12650-69-0 (Mupirocin) Hazard Symbols N/A
Synonyms

5,9-Anhydro-2,3,4,8-tetradeoxy-8-[[3-(2-hydroxy-1-methylpropyl)oxiranyl]methyl]-3-methyl-[2E,8[2S,3S(1S,2S)]]-L-talonon-2-enonic acid 8-carboxyoctyl ester;Mupirocinum;Pseudomonic acid;Pseudomonic acid A;UNII-D0GX863OA5;

Article Data 4

Mupirocin Specification

Mupirocin is one kind of white crystalline solid. The IUPAC name of Mupirocin is 9-[(E)-4-[(2S,3R,4R,5S)-3,4-dihydroxy-5-[[(2S,3S)-3-[(2S,3S)-3-hydroxybutan-2-yl]oxiran-2-yl]methyl]oxan-2-yl]-3-methylbut-2-enoyl]oxynonanoic acid. Besides, Mupirocin belongs to active pharmaceutical ingredients; intermediates & fine chemicals; pharmaceuticals. It is an antibiotic originally isolated from Pseudomonas fluorescens NCIMB 10586, developed by Beecham. In addition, the Classification Code of it is Anti-Bacterial Agents; Anti-Infective Agents; Antibacterial [topical]; Drug / Therapeutic Agent; Enzyme Inhibitors; Natural Product; Protein Synthesis Inhibitors. The water solubility of Mupirocin is 2.65e-02 g/l. In other words, it can soluble in water which is 12 mg/mL.

Physical properties about Mupirocin are: (1)ACD/LogP: 3.443; (2)# of Rule of 5 Violations: 1; (3)ACD/LogD (pH 5.5): 2.64; (4)ACD/LogD (pH 7.4): 0.85; (5)ACD/BCF (pH 5.5): 38.70; (6)ACD/BCF (pH 7.4): 1.00; (7)ACD/KOC (pH 5.5): 282.50; (8)ACD/KOC (pH 7.4): 4.53; (9)#H bond acceptors: 9; (10)#H bond donors: 4; (11)#Freely Rotating Bonds: 20; (12)Index of Refraction: 1.524; (13)Molar Refractivity: 129.517 cm3; (14)Molar Volume: 423.051 cm3; (15)Polarizability: 51.344 10-24cm3; (16)Surface Tension: 49.0620002746582 dyne/cm; (17)Density: 1.183 g/cm3; (18)Flash Point: 216.524 °C; (19)Enthalpy of Vaporization: 113.012 kJ/mol; (20)Boiling Point: 672.313 °C at 760 mmHg

Preparation of Mupirocin: Mupirocin is obtained by the Pseudomonas fluorescens which produces a class of substances, including Pseudomonas acid A, B, C, D. Mupirocin is one of the major metabolites Pseudomonas acid A.

Uses of Mupirocin: Mupirocin is bacteriostatic at low concentrations and bactericidal at high concentrations. It is used topically and is effective against Gram-positive bacteria, including MRSA. treatment for bacterial skin infections. Mupirocin is a topically used antibiotic from a strain of Pseudomonas fluorescens. It has shown excellent activity against gram-positive staphylococci and streptococci. The antibiotic is used primarily for the treatment of primary and secondary skin disorders, nasal infections, and wound healing.

You can still convert the following datas into molecular structure:
(1)InChI=1S/C26H44O9/c1-16(13-23(30)33-11-9-7-5-4-6-8-10-22(28)29)12-20-25(32)24(31)19(15-34-20)14-21-26(35-21)17(2)18(3)27/h13,17-21,24-27,31-32H,4-12,14-15H2,1-3H3,(H,28,29)/b16-13+/t17-,18-,19-,20-,21-,24+,25-,26-/m0/s1;
(2)InChIKey=MINDHVHHQZYEEK-HBBNESRFSA-N;
(3)SmilesC1[C@@H]([C@H]([C@H]([C@@H](O1)C\C(=C\C(OCCCCCCCCC(O)=O)=O)C)O)O)C[C@H]1[C@@H](O1)[C@H]([C@H](C)O)C;

The following are the toxicity data which has been tested.

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 1638mg/kg (1638mg/kg)   United States Patent Document. Vol. #4206224,
mouse LD50 oral 5gm/kg (5000mg/kg)   United States Patent Document. Vol. #4206224,
mouse LD50 subcutaneous 4gm/kg (4000mg/kg)   United States Patent Document. Vol. #4206224,
rat LD50 intravenous 1310mg/kg (1310mg/kg)   United States Patent Document. Vol. #4206224,
rat LD50 oral 5gm/kg (5000mg/kg)   United States Patent Document. Vol. #4206224,
rat LD50 subcutaneous 5gm/kg (5000mg/kg)   United States Patent Document. Vol. #4206224,

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