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N-(Trimethylsilyl)acetamide

  • Name N-(Trimethylsilyl)acetamide
  • EINECS236-565-7
  • CAS No. 13435-12-6
  • Density0.859 g/cm3
  • PSA29.10000
  • LogP1.34830
  • SolubilityREACTS with water
  • Melting Point46-49 °C(lit.)
  • FormulaC5H13 N O Si
  • Boiling Point84ºC 18 mm Hg(lit.),190.2 °C at 760 mmHg
  • Molecular Weight131.25
  • Flash Point70 ºC
  • Transport InformationUN1325
  • AppearanceWHITE TO YELLOWISH CRYSTALLINE MASS
  • SafetyPoison by intraperitoneal route. When heated to decomposition it emits toxic fumes of NOx.
  • Risk CodesR11;R36/37/38   
  • Molecular Structure
    Molecular Structure of 13435-12-6 (N-(Trimethylsilyl)acetamide)
  • Hazard Symbols
  • Synonyms
  • Article Data19

N-(Trimethylsilyl)acetamide Chemical Properties

Chemistry informtion about N-Trimethylsilylacetamide (CAS NO.13435-12-6) is:
IUPAC Name: N-Trimethylsilylacetamide
Synonyms: (Acetylamino)Trimethylsilane ; N-(Trimethylsilyl)-Acetamid ; N-Trimethylsilylacetamide ; Trimethylsilylacetamide ; Tmsa ; Tms Acetamide ; N-Trimethylsilylacetamidea.R. ; Acetamide, N-(Trimethylsilyl)-
MF: C5H13NOSi
MW: 131.25
EINECS: 236-565-7
Density: 0.859 g/cm3
Melting Point: 46-49 °C(lit.)
Flash Point: 44.1 °C
Boiling Point: 190.2 °C at 760 mmHg
Vapour Pressure: 0.548 mmHg at 25°C
Enthalpy of Vaporization: 42.64 kJ/mol
Storage temp.:  Flammables area
Sensitive Moisture: Sensitive
BRN: 741928 
Product Categories: Analytical Chemistry ; GC Derivatizing Reagents ; Si (Classes of Silicon Compounds) ; Silicon Compounds (for Synthesis) ; Silylacetamides ; Silylation (GC Derivatizing Reagents) ; Si-N Compounds ; Synthetic Organic Chemistry ; Trimethylsilylation (GC Derivatizing Reagents)
Following is the molecular structure of N-Trimethylsilylacetamide (CAS NO.13435-12-6) is:

N-(Trimethylsilyl)acetamide Production

Its preparation products is cefdinir .

N-(Trimethylsilyl)acetamide Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LDLo intraperitoneal 350mg/kg (350mg/kg)

immunological including allergic: decreased immune response

Personal Communication from G.D. Stoner, Dept. of Community Medicine, School of Medicine, Univ. of California, La Jolla, CA 92037, May 25, 1975Vol. 27MAY1975,

N-(Trimethylsilyl)acetamide Consensus Reports

Reported in EPA TSCA Inventory.

N-(Trimethylsilyl)acetamide Safety Profile

Poison by intraperitoneal route. When heated to decomposition it emits toxic fumes of NOx.
Hazard Codes:
IrritantXi
FlammableF
Risk Statements:
R36/37/38:Irritating to eyes, respiratory system and skin. 
R11:Highly flammable.
Safety Statements:
S37/39:Wear suitable gloves and eye/face protection. 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
RIDADR: 1325
WGK Germany:3
RTECS: AD0250000
F:
F 10: Keep under argon.
F 21: Sensitive to humidity.
TSCA: Yes
HazardClass: 4.1
PackingGroup: III

N-(Trimethylsilyl)acetamide Specification

 N-Trimethylsilylacetamide (CAS NO.13435-12-6) is a white to yellowish crystalline mass.
First Aid Measures:
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin: Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion: Get medical aid. Wash mouth out with water.
Inhalation: Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician: Treat symptomatically and supportively. 
Handling and Storage:
Handling: Use spark-proof tools and explosion proof equipment. Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes. Avoid ingestion and inhalation.
Storage: Keep away from sources of ignition. Store in a cool, dry place. Store in a tightly closed container. Flammables-area.

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