- Naftifine
- Naftifine hydrochloride
- 65473-13-4N-Methyl-1-naphthalenemethylamine hydrochloride
- 65473-14-51-Naphthalenemethanamine,N-methyl-N-[(2E)-3-phenyl-2-propen-1-yl]-, hydrochloride (1:1)
- 65-47-4Cytidine5'-(tetrahydrogen triphosphate)
- 65474-79-59H-Pyrido[3,4-b]indole-3-methanol
- 6547-53-1Benzeneacetic acid,4-(phenylmethoxy)-
- 654-76-2Benzene,1-methoxy-4-nitro-2-(trifluoromethyl)-
- 65478-62-8Acetamide,N-(5-methyl-1-oxido-2-pyridinyl)-
- 6548-09-0Tryptophan, 5-bromo-
- 65481-56-3Benzene,1-(2-methylpropoxy)-4-phenoxy-
- 6548-30-71,3-Naphthalenedisulfonicacid,8-[2-[3,3'-dimethoxy-4'-[2-[4-[[(4-methylphenyl)sulfonyl]oxy]phenyl]diazenyl][1,1'-biphenyl]-4-yl]diazenyl]-7-hydroxy-,sodium salt (1:2)
Hot Products
- 104987-11-3Tacrolimus
- 141-53-7Sodium formate
- 8001-54-5Quaternary ammonium compounds, alkylbenzyldimethyl, chlorides
- 9003-39-8Povidone
- 10161-34-9Trenbolone acetate
- 402957-28-2Telaprevir
- 68-19-9Cyanocobalamin
- 7631-86-9Silicon dioxide
- 302-79-4Tretinoin
- 77-92-9Citric acid
|
Basic Information |
|
Post buying leads |
|
Suppliers |
|
Cas Database |
| Name |
Naftifine |
EINECS | N/A |
| CAS No. | 65472-88-0 | Density | 1.082 g/cm3 |
| PSA | 3.24000 | LogP | 5.78700 |
| Solubility | N/A | Melting Point |
177 °C |
| Formula | C21H21N | Boiling Point | 440.1 °C at 760 mmHg |
| Molecular Weight | 287.404 | Flash Point | 194.4 °C |
| Transport Information | N/A | Appearance | N/A |
| Safety | Risk Codes | R22; R36/37/38 | |
| Molecular Structure |
|
Hazard Symbols |
 Xn, Xi
|
| Synonyms |
1-Naphthalenemethanamine,N-methyl-N-(3-phenyl-2-propenyl)-, (E)-;1-Naphthalenemethanamine, N-methyl-N-[(2E)-3-phenyl-2-propenyl]-(9CI);Naftifine;Naftifungin; |
Article Data | 27 |
Naftifine Synthetic route
- 50-00-0
formaldehyd
- 92610-10-1
(E)-N-(naphthalen-1-ylmethyl)-3-phenylprop-2-en-1-amine
- 65472-88-0
naftifine
| Conditions | Yield |
|---|---|
| With sodium dihydrogen phosphate In 1,4-dioxane; water at 60℃; for 0.166667h; | 100% |
| With sodium dihydrogenphosphate In 1,4-dioxane at 60℃; for 0.333333h; | 91% |
| With sodium tetrahydroborate 1.) CH3OH, H2O, reflux, 30 min, 2.) CH3OH, H2O, RT, 3 h; Yield given. Multistep reaction; |
| Conditions | Yield |
|---|---|
| Pt(COD)Cl2; bis[2-(diphenylphosphino)phenyl] ether In 1,4-dioxane for 12h; Heating; | 98% |
| With 1,1'-bis-(diphenylphosphino)ferrocene; bis(η3-allyl-μ-chloropalladium(II)) In methanol at 20℃; for 12h; Temperature; Solvent; Inert atmosphere; | 96% |
| With 1,10-Phenanthroline; palladium diacetate In toluene at 100℃; for 17h; Inert atmosphere; Schlenk technique; regioselective reaction; | 83% |
| Stage #1: N-methyl-1-naphthalenemethylamine; (2E)-3-phenyl-2-propen-1-ol With manganese(IV) oxide; polymer-bound trimethyl ammonium cyanoborohydride In dichloromethane for 5h; Stage #2: With acetic acid for 17h; | 72% |
| With triscarbonyl‐(η4–3,4‐bis(4‐methoxyphenyl)‐2,5‐diphenylcyclopenta‐2,4‐dienone)iron In nitromethane; toluene at 130℃; for 24h; Schlenk technique; Inert atmosphere; | 61% |
| Conditions | Yield |
|---|---|
| With bis(η3-allyl-μ-chloropalladium(II)); Methyl formate; potassium carbonate; bis[2-(diphenylphosphino)phenyl] ether In water at 20℃; for 0.333333h; chemoselective reaction; | 98% |
| Conditions | Yield |
|---|---|
| With potassium phosphate; 18-crown-6 ether; phenylsilane In tetrahydrofuran at 80℃; for 36h; Glovebox; Molecular sieve; Schlenk technique; | 96% |
- 92610-10-1
(E)-N-(naphthalen-1-ylmethyl)-3-phenylprop-2-en-1-amine
- 75-05-8
acetonitrile
- 65472-88-0
naftifine
| Conditions | Yield |
|---|---|
| With 18-crown-6 ether; carbon dioxide at 80℃; under 750.075 Torr; for 72h; Inert atmosphere; Schlenk technique; Glovebox; | 95% |
- 98977-94-7
(±)-3-(N-methyl-N-((naphthalen-5-yl)methyl)amino)-1-phenylpropan-1-ol
- 65472-88-0
naftifine
| Conditions | Yield |
|---|---|
| With hydrogenchloride In water Reflux; | 90% |
| With hydrogenchloride for 2h; Heating; |
- 4780-79-4
1-naphthalene methanol
- 60960-88-5, 93085-46-2, 83554-67-0
(E)-N-methylcinnamylamine
- 65472-88-0
naftifine
| Conditions | Yield |
|---|---|
| Stage #1: 1-naphthalene methanol; (E)-N-methylcinnamylamine With manganese(IV) oxide; polymer-bound trimethyl ammonium cyanoborohydride In dichloromethane for 5h; Stage #2: With acetic acid for 17h; | 62% |
| Conditions | Yield |
|---|---|
| With potassium phosphate; bis(η3-allyl-μ-chloropalladium(II)); triphenylphosphine In tetrahydrofuran; water at 80℃; for 16h; Sealed tube; Inert atmosphere; Schlenk technique; | 62% |
- 50-00-0
formaldehyd
- 6783-05-7
trans-2-phenylvinylboronic acid
- 14489-75-9
N-methyl-1-naphthalenemethylamine
- 65472-88-0
naftifine
| Conditions | Yield |
|---|---|
| Mechanism; multistep reaction; other substrates, other boronic acids; E-selectivity; | |
| 1) dioxane, 90 deg C, 10 min, 2) dioxane, 90 deg C, 10 min; Yield given. Multistep reaction; |
- 118-31-0
(naphth-1-yl)methylamine
- 65472-88-0
naftifine
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1.1: manganese dioxide; NaBH4; 4A MS / CH2Cl2 / 17 h / Heating 1.2: 86 percent / MeOH / 0.67 h / 0 - 20 °C 2.1: 91 percent / NaH2PO4 / dioxane / 0.33 h / 60 °C View Scheme | |
| Multi-step reaction with 3 steps 1: benzene / Heating 2: 100 percent / NaBH4 / methanol / 0.33 h / 40 °C 3: 2.) NaBH4 / 1.) CH3OH, H2O, reflux, 30 min, 2.) CH3OH, H2O, RT, 3 h View Scheme | |
| Multi-step reaction with 3 steps 2: NaBH4 3: 100 percent / NaH2PO3 / H2O; dioxane / 0.17 h / 60 °C View Scheme | |
| Multi-step reaction with 2 steps 1.1: dichloro( 1,5-cyclooctadiene)platinum(ll); bis[2-(diphenylphosphino)phenyl] ether / 1,4-dioxane / 110 °C / Schlenk technique; Inert atmosphere 1.2: Schlenk technique; Inert atmosphere; Reflux 2.1: [1,3-bis(2,4,6-trimethylphenyl)imidazol]-2-ylidene; diphenylsilane / N,N-dimethyl-formamide / 48 h / 50 °C / 760.05 Torr View Scheme |
Naftifine Specification
The Naftifine, with the CAS registry number 65472-88-0, is also known as N-trans-Cinnamyl-N-methyl-(1-naphthylmethyl)amine. This chemical's molecular formula is C21H21N and molecular weight is 287.40. Its IUPAC name is called (E)-N-methyl-N-(naphthalen-1-ylmethyl)-3-phenylprop-2-en-1-amine. This chemical's classification codes are Anti-Infective Agents; Antifungal agents. Naftifine is an allylamine antifungal drug for the topical treatment of tinea pedis, tinea cruris, and tinea corporis.
Physical properties of Naftifine: (1)ACD/LogP: 5.80; (2)# of Rule of 5 Violations: 1; (3)ACD/LogD (pH 5.5): 3.4; (4)ACD/LogD (pH 7.4): 5.11; (5)ACD/BCF (pH 5.5): 60.47; (6)ACD/BCF (pH 7.4): 3087; (7)ACD/KOC (pH 5.5): 136.99; (8)ACD/KOC (pH 7.4): 6993.87; (9)#H bond acceptors: 1; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 5; (12)Index of Refraction: 1.655; (13)Molar Refractivity: 97.45 cm3; (14)Molar Volume: 265.4 cm3; (15)Surface Tension: 46 dyne/cm; (16)Density: 1.082 g/cm3; (17)Flash Point: 194.4 °C; (18)Enthalpy of Vaporization: 69.71 kJ/mol; (19)Boiling Point: 440.1 °C at 760 mmHg; (20)Vapour Pressure: 6.07E-08 mmHg at 25°C.
Preparation: this chemical can be prepared by formaldehyde and N-(3-phenyl-2-propenyl)-1-naphthalenemethanamine. This reaction will need reagent NaH2PO3 and solvent H2O, dioxane. The reaction time is 10 min with reaction temperature of 60 ℃. The yield is about 100%.
.png)
You can still convert the following datas into molecular structure:
(1)Canonical SMILES: CN(CC=CC1=CC=CC=C1)CC2=CC=CC3=CC=CC=C32
(2)Isomeric SMILES: CN(C/C=C/C1=CC=CC=C1)CC2=CC=CC3=CC=CC=C32
(3)InChI: InChI=1S/C21H21N/c1-22(16-8-11-18-9-3-2-4-10-18)17-20-14-7-13-19-12-5-6-15-21(19)20/h2-15H,16-17H2,1H3/b11-8+
(4)InChIKey: OZGNYLLQHRPOBR-DHZHZOJOSA-N
What can I do for you?
Get Best Price
