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Phenobarbital sodium

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Phenobarbital sodium

EINECS 200-322-3
CAS No. 57-30-7 Density N/A
PSA 81.59000 LogP 0.54170
Solubility 1 g/mL in water Melting Point 175°C
Formula C12H11N2NaO3 Boiling Point 384.7°C at 760 mmHg
Molecular Weight 302.265 Flash Point 186.5°C
Transport Information UN 2811 6.1/PG 3 Appearance Odorless white crystalline powder
Safety 22-36/37/39-45 Risk Codes 25-40-43
Molecular Structure Molecular Structure of 57-30-7 (Phenobarbital sodium) Hazard Symbols ToxicT

2,4,6(1H,3H,5H)-Pyrimidinetrione,5-ethyl-5-phenyl-, monosodium salt (9CI);Barbituric acid, 5-ethyl-5-phenyl-,sodium salt (8CI);5-Ethyl-5-phenylbarbituric acid sodium;Gardenal sodium;Linasen;Luminal sodium;PBS;Phenemalum;Phenobal;Phenobal sodium;Phenobarbital sodium;Phenobarbitone sodium;Sodium5-ethyl-5-phenylbarbiturate;Sodium ethylphenylbarbiturate;Sodium luminal;Sodium phenobarbital;Sodium phenobarbitone;Sodium phenylethylbarbiturate;Sodium phenylethylmalonylurea;Sol phenobarbitone;Solublephenobarbital;Soluble phenobarbitone;

Article Data 5

Phenobarbital sodium Chemical Properties

IUPAC Name: Sodium 5-ethyl-4,6-dioxo-5-phenyl-1H-pyrimidin-2-olate
Synonyms : Sodium 5-ethyl-5-phenylbarbiturate ; 5-Ethyl-5-phenyl-2,4,6-(1H,3H,5H)pyrimidinetrione monosodium salt ; Luminal sodium
Product Categories: Heterocyclic Compounds
Molecular Structure :
Molecular Formula: C12H11N2NaO3
Molecular Weight: 254.22
CAS NO: 57-30-7
EINECS: 200-322-3
Mol File: 57-30-7.mol
Melting point: 175°C
Water Solubility : >=10 g/100 mL at 20 ºC
Merck : 13,7319
Appearance: Sodium luminal (CAS NO: 57-30-7) is odorless white crystalline powder.

Phenobarbital sodium Uses

1. Sedation: such as anxiety, irritability, hyperthyroidism, high blood pressure, functional nausea, pyloric spasm embolism in children.
2. Hypnosis: even for refractory insomnia, but often after waking fatigue, sleepiness and other lingering effects.
3. Anticonvulsant: Sodium luminal (CAS NO: 57-30-7) is used to combat the poisoning or high fever caused by central stimulant, tetanus, encephalitis, brain hemorrhage and other diseases caused by convulsions.
4. Epilepsy: Sodium luminal (CAS NO: 57-30-7) is used for prevention and treatment of grand mal epilepsy,but also can be used for status epilepticus.
5. Anesthetic administration.
6. compatibility with antipyretic analgesics to enhance its role.
7. The treatment of neonatal kernicterus.

Phenobarbital sodium Toxicity Data With Reference


dnr-esc 400 µg/well

    ENMUDM    Environmental Mutagenesis. 3 (1981),429.

msc-mus:lym 5 mmol/L

    MUREAV    Mutation Research. 110 (1983),147.

orl-man TDLo:36 mg/kg:CNS,GIT

    BMJOAE    British Medical Journal. 1 (1955),1238.

orl-rat LD50:150 mg/kg

    JPETAB    Journal of Pharmacology and Experimental Therapeutics. 138 (1962),224.

ipr-rat LD50:152 mg/kg

    ARZNAD    Arzneimittel-Forschung. Drug Research. 33 (1983),1155.

scu-rat LD50:195 mg/kg

    NYKZAU    Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. 56 (1960),377.

ivn-rat LD50:83 mg/kg

    JMCMAR    Journal of Medicinal Chemistry. 8 (1965),220.

idu-rat LDLo:100 mg/kg

    ARZNAD    Arzneimittel-Forschung. Drug Research. 25 (1975),1037.

orl-mus LD50:200 mg/kg

    JPETAB    Journal of Pharmacology and Experimental Therapeutics. 127 (1959),318.

ipr-mus LD50:123 mg/kg

    JPETAB    Journal of Pharmacology and Experimental Therapeutics. 87 (1946),265.

Phenobarbital sodium Consensus Reports

IARC Cancer Review: Animal Sufficient Evidence IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 13 ,1977,p. 157.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . EPA Genetic Toxicology Program.

Phenobarbital sodium Safety Profile

Hazard Codes  VeryT+
Risk Statements 25-40-43 
R25 :Toxic if swallowed. 
R40:Limited evidence of a carcinogenic effect. 
R43:May cause sensitization by skin contact.
Safety Statements 22-36/37/39-45
S22:Do not breathe dust. 
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) 
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
RIDADR UN 2811 6.1/PG 3
WGK Germany -
RTECS CQ7000000
HazardClass 6.1(b)
PackingGroup III


Phenobarbital sodium Specification

1.General Description: Odorless white crystalline powder. Aqueous solutions are alkaline to litmus and phenolphthalein (pH approximately 9.3). Bitter taste. A narcotic.
2.Air & Water Reactions :Hygroscopic. May be sensitive to prolonged exposure to air. Water soluble. Aqueous solutions are unstable, but may be kept at or below 50°F for a few days.
3.Reactivity Profile: Phenobarbital sodium can react with strong oxidizing agents. Incompatible with ammonium salts and chloral hydrate. Also incompatible with acids and acidic substances .
4.Fire Hazard :Flash point data for Phenobarbital sodium are not available; however, Phenobarbital sodium is probably combustible.