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Name Phenobarbital sodium
EINECS200-322-3
CAS No. 57-30-7
DensityN/A
PSA81.59000
LogP0.54170
Solubility1 g/mL in water
Melting Point175°C
FormulaC₁₂H₁₁N₂NaO₃
Boiling Point384.7°C at 760 mmHg
Molecular Weight302.265
Flash Point186.5°C
Transport InformationUN 2811 6.1/PG 3
AppearanceOdorless white crystalline powder
Safety22-36/37/39-45
Risk Codes25-40-43
Molecular Structure
Hazard SymbolsT
SynonymsT
Article Data5

Phenobarbital sodium Chemical Properties

IUPAC Name: Sodium 5-ethyl-4,6-dioxo-5-phenyl-1H-pyrimidin-2-olate
Synonyms : Sodium 5-ethyl-5-phenylbarbiturate ; 5-Ethyl-5-phenyl-2,4,6-(1H,3H,5H)pyrimidinetrione monosodium salt ; Luminal sodium
Product Categories: Heterocyclic Compounds
Molecular Structure :
Molecular Formula: C₁₂H₁₁N₂NaO₃
Molecular Weight: 254.22
CAS NO: 57-30-7
EINECS: 200-322-3
Mol File: 57-30-7.mol
Melting point: 175°C
Water Solubility : >=10 g/100 mL at 20 ºC
Merck : 13,7319
Appearance: Sodium luminal (CAS NO: 57-30-7) is odorless white crystalline powder.

Phenobarbital sodium Uses

1. Sedation: such as anxiety, irritability, hyperthyroidism, high blood pressure, functional nausea, pyloric spasm embolism in children.
2. Hypnosis: even for refractory insomnia, but often after waking fatigue, sleepiness and other lingering effects.
3. Anticonvulsant: Sodium luminal (CAS NO: 57-30-7) is used to combat the poisoning or high fever caused by central stimulant, tetanus, encephalitis, brain hemorrhage and other diseases caused by convulsions.
4. Epilepsy: Sodium luminal (CAS NO: 57-30-7) is used for prevention and treatment of grand mal epilepsy,but also can be used for status epilepticus.
5. Anesthetic administration.
6. compatibility with antipyretic analgesics to enhance its role.
7. The treatment of neonatal kernicterus.

Phenobarbital sodium Toxicity Data With Reference

1.	dnr-esc 400 µg/well	ENMUDM Environmental Mutagenesis. 3 (1981),429.
2.	msc-mus:lym 5 mmol/L	MUREAV Mutation Research. 110 (1983),147.
3.	orl-man TDLo:36 mg/kg:CNS,GIT	BMJOAE British Medical Journal. 1 (1955),1238.
4.	orl-rat LD50:150 mg/kg	JPETAB Journal of Pharmacology and Experimental Therapeutics. 138 (1962),224.
5.	ipr-rat LD50:152 mg/kg	ARZNAD Arzneimittel-Forschung. Drug Research. 33 (1983),1155.
6.	scu-rat LD50:195 mg/kg	NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. 56 (1960),377.
7.	ivn-rat LD50:83 mg/kg	JMCMAR Journal of Medicinal Chemistry. 8 (1965),220.
8.	idu-rat LDLo:100 mg/kg	ARZNAD Arzneimittel-Forschung. Drug Research. 25 (1975),1037.
9.	orl-mus LD50:200 mg/kg	JPETAB Journal of Pharmacology and Experimental Therapeutics. 127 (1959),318.
10.	ipr-mus LD50:123 mg/kg	JPETAB Journal of Pharmacology and Experimental Therapeutics. 87 (1946),265.

Phenobarbital sodium Consensus Reports

IARC Cancer Review: Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 13 ,1977,p. 157.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . EPA Genetic Toxicology Program.

Phenobarbital sodium Safety Profile

Hazard Codes Very T+
Risk Statements 25-40-43
R25 :Toxic if swallowed.
R40:Limited evidence of a carcinogenic effect.
R43:May cause sensitization by skin contact.
Safety Statements 22-36/37/39-45
S22:Do not breathe dust.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
RIDADR UN 2811 6.1/PG 3
WGK Germany -
RTECS CQ7000000
HazardClass 6.1(b)
PackingGroup III

Phenobarbital sodium Specification

1.General Description: Odorless white crystalline powder. Aqueous solutions are alkaline to litmus and phenolphthalein (pH approximately 9.3). Bitter taste. A narcotic.
2.Air & Water Reactions :Hygroscopic. May be sensitive to prolonged exposure to air. Water soluble. Aqueous solutions are unstable, but may be kept at or below 50°F for a few days.
3.Reactivity Profile: Phenobarbital sodium can react with strong oxidizing agents. Incompatible with ammonium salts and chloral hydrate. Also incompatible with acids and acidic substances .
4.Fire Hazard :Flash point data for Phenobarbital sodium are not available; however, Phenobarbital sodium is probably combustible.

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