(S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol

Base Information Edit

Chemical Name:(S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol
CAS No.:877397-65-4
Molecular Formula:C8H7Cl2FO
Molecular Weight:209.047
Hs Code.:2906299090
Mol file:877397-65-4.mol

Synonyms:(1S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol;(S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol;

Suppliers and Price of (S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol
50g
$ 1075.00

Matrix Scientific
(S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol 95%
1g
$ 20.00

Matrix Scientific
(S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol 95%
5g
$ 54.00

J&W Pharmlab
(S)-1-(2,6-Dichloro-3-fluoro-phenyl)-ethanol 97%
5g
$ 6880.00

J&W Pharmlab
(S)-1-(2,6-Dichloro-3-fluoro-phenyl)-ethanol 97%
1g
$ 1880.00

Crysdot
(S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol 95%
10g
$ 80.00

ChemScene
(S)-1-(2,6-dichloro-3-fluorophenyl)ethanol 99.98%
10g
$ 81.00

ChemScene
(S)-1-(2,6-dichloro-3-fluorophenyl)ethanol 99.98%
25g
$ 131.00

ChemScene
(S)-1-(2,6-dichloro-3-fluorophenyl)ethanol 99.98%
100g
$ 517.00

Chemenu
(S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol 95+%
1000g
$ 552.00

Total 151 raw suppliers

Chemical Property of (S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol Edit

Chemical Property:

Vapor Pressure:0.006mmHg at 25°C
Refractive Index:1.547
Boiling Point:261.329 °C at 760 mmHg
PKA:13.30±0.20(Predicted)
Flash Point:111.848 °C
PSA：20.23000
Density:1.407 g/cm³
LogP:3.18580
Storage Temp.:2-8°C

Purity/Quality:

99% ^*data from raw suppliers

(S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses (S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol is an intermediate in the synthetic preparation of Crizotinib (C785000), a potent and selective dual inhibitor of mesenchymal-epithelial transition factor ( c-MET) kinase and anaplastic lymphoma kinase (ALK). Crizotinib is a potential antitumor agent. (S) -1- (2,6-dichloro-3-fluorophenyl) ethanol(C8H7C12FO) is synthesized (R)-3-[l-(2, 6-dichloro-3-fluoro-benzene)- The key intermediate of ethoxy-5- (l-piperidine-4-hydroxy-1 hydrogen-pyrazole-4-hydroxy) -pyrimidine-2-indane. And (R)-3-[l-(2,6-dichloro-3-fluoro-benzene)-ethoxy-5-(l-piperidine-4-hydroxy-1 hydrogen-pyrazole-4-hydroxy) -Pyrimidine-2-indane is a small molecule kinase inhibitor for the treatment of locally advanced or metastatic non-small cell lung cancer (NSCLC) positive for anaplastic lymphohematokinase (ALK). (S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol is an intermediate in the synthetic preparation of Crizotinib (C785000), a potent and selective dual inhibitor of mesenchymal-epithelial transition factor (c-MET) kinase and anaplastic lymphoma kinase (ALK). Crizotinib is a potential antitumor agent.

Technology Process of (S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol

There total 12 articles about (S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 290835-85-7
2',6'-dichloro-3'-fluoroacetophenone

: 877397-65-4
(S)‐1‐(2,6-dichloro-3-fluorophenyl)ethanol

: 330156-50-8
(R)-1-(2,6-dichloro-3-fluorophenyl)ethan-1-ol

Guidance literature:: With RuBr₂[(S,S)-2,4-bis(diphenylphosphino)pentane](2-picolylamine); potassium tert-butylate; hydrogen; In isopropyl alcohol; at 40 ℃; for 21h; Autoclave; Inert atmosphere;

Reference yield: 100.0%

: 290835-85-7
2',6'-dichloro-3'-fluoroacetophenone

: 877397-65-4
(S)‐1‐(2,6-dichloro-3-fluorophenyl)ethanol

Guidance literature:: With RuBr₂[(S,S)-2,4-bis(diphenylphosphino)pentane](2-aminomethyl-3,5-dimethylpyridine); potassium tert-butylate; hydrogen; In isopropyl alcohol; at 40 ℃; for 21h; Reagent/catalyst; Concentration; Autoclave; Inert atmosphere;

Reference yield: 94.9%

: 877397-68-7
(1S)-1-(2,6-dichloro-3-fluorophenyl)ethyl acetate

: 877397-65-4
(S)‐1‐(2,6-dichloro-3-fluorophenyl)ethanol

Guidance literature:: (1S)-1-(2,6-dichloro-3-fluorophenyl)ethyl acetate; With sodium methylate; In methanol; at 0 - 20 ℃; for 4h;

With sodium acetate; acetic acid; In water; pH=7;

upstream raw materials:

(1S)-1-(2,6-dichloro-3-fluorophenyl)ethyl acetate

1-(2,6-dichloro-3-fluorophenyl)ethanol

2',6'-dichloro-3'-fluoroacetophenone

1-(2,6-dichloro-3-fluorophenyl)ethyl acetate

Downstream raw materials:

3-[(R)-1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridin-2-ylamine

(R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethyoxyl)-2-nitropyridine

2',6'-dichloro-3'-fluoroacetophenone

Refernces Edit

1、 Ji, Pengfei,Park, Jeeyoung,Gu, Yang,Clark, Douglas S.,Hartwig, John F.. "Abiotic reduction of ketones with silanes catalysed by carbonic anhydrase through an enzymatic zinc hydride". . p. 312 - 318. Retrieved 2021/02/26.
2、 Chen, Jiachen,Hou, Huacui,Ling, Fei,Nian, Sanfei,Wu, Feifei,Xu, Min,Yi, Xiao,Zhong, Weihui. "Manganese-Catalyzed Enantioselective Hydrogenation of Simple Ketones Using an Imidazole-Based Chiral PNN Tridentate Ligand". supporting information. p. 285 - 289. Retrieved 2020/02/18.

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Encyclopedia

Technology Process of (S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol

(S)-1-(2,6-Dichloro-3-fluorophenyl)ethanol

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