5-BROMO-N,N-DIMETHYL-3-PYRIDINECARBOXAMIDE

Base Information

• Chemical Name: 5-BROMO-N,N-DIMETHYL-3-PYRIDINECARBOXAMIDE
• CAS No.: 292170-96-8
• Molecular Formula: C8H9BrN2O
• Molecular Weight: 229.076
• Hs Code.: 2933399090
• Mol file: 292170-96-8.mol

Synonyms:5-BROMO-N,N-DIMETHYLNICOTINAMIDE;5-BROMO-N,N-DIMETHYL-3-PYRIDINECARBOXAMIDE;

Chemical Property of 5-BROMO-N,N-DIMETHYL-3-PYRIDINECARBOXAMIDE

Chemical Property:

• PSA: 33.20000
• LogP: 1.54590
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

5-Bromo-N,N-dimethylnicotinamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-BROMO-N,N-DIMETHYL-3-PYRIDINECARBOXAMIDE

There total 4 articles about 5-BROMO-N,N-DIMETHYL-3-PYRIDINECARBOXAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

→ 5-bromo-N,N-dimethylnicotinamide (292170-96-8)

Guidance literature:

Reference yield: 89.0%

5-bromonicotinoyl chloride (39620-02-5) + dimethyl amine (124-40-3) → 5-bromo-N,N-dimethylnicotinamide (292170-96-8)

Guidance literature:

With pyridine; In tetrahydrofuran; at 20 ℃; for 6h;

Reference yield:

3-bromo-5-(N-methylcarbamoyl)pyridine (153435-68-8) + methyl iodide (74-88-4) → 5-bromo-N,N-dimethylnicotinamide (292170-96-8)

Guidance literature:

3-bromo-5-(N-methylcarbamoyl)pyridine; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 45 ℃; for 1h;

methyl iodide; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 1h; Cooling with ice;

upstream raw materials:

5-bromonicotinoyl chloride

dimethyl amine

3-bromo-5-(N-methylcarbamoyl)pyridine

methyl iodide

Refernces

• 1、 -. "NOVEL NICOTINAMIDE DERIVATIVES OR SALTS THEREOF". Paragraph 0585; 0586. . Retrieved 2018/09/08.
• 2、 -. "PYRROLO-PYRIDINE KINASE MODULATORS". Page/Page column 52-53. . Retrieved 2008/12/04.