(2E)-3-(4-Chlorophenyl)-N-[(1S)-2-oxo-2-({2-oxo-2-[4-(3-pyridyloxy)-1-piperidinyl]ethyl}amino)-1-(2-pyridylmethyl)ethyl]-acrylamide

Base Information

• Chemical Name: (2E)-3-(4-Chlorophenyl)-N-[(1S)-2-oxo-2-({2-oxo-2-[4-(3-pyridyloxy)-1-piperidinyl]ethyl}amino)-1-(2-pyridylmethyl)ethyl]-acrylamide
• CAS No.: 442198-32-5
• Molecular Formula: C₂₉H₃₀ClN₅O₄
• Molecular Weight: 548.041
• Mol file: 442198-32-5.mol

Synonyms:

Chemical Property of (2E)-3-(4-Chlorophenyl)-N-[(1S)-2-oxo-2-({2-oxo-2-[4-(3-pyridyloxy)-1-piperidinyl]ethyl}amino)-1-(2-pyridylmethyl)ethyl]-acrylamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2E)-3-(4-Chlorophenyl)-N-[(1S)-2-oxo-2-({2-oxo-2-[4-(3-pyridyloxy)-1-piperidinyl]ethyl}amino)-1-(2-pyridylmethyl)ethyl]-acrylamide

There total 11 articles about (2E)-3-(4-Chlorophenyl)-N-[(1S)-2-oxo-2-({2-oxo-2-[4-(3-pyridyloxy)-1-piperidinyl]ethyl}amino)-1-(2-pyridylmethyl)ethyl]-acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[[(2S)-2-[[(2E)-3-(4-chlorophenyl)-2-propenoyl]amino]-3-(pyridin-2-yl)propanoyl]amino]acetic acid (337530-31-1) + 1,1-dimethylethyl 4-(3'-pyridinyloxy)-1-piperidinecarboxylate (310881-47-1) → (2E)-3-(4-Chlorophenyl)-N-[(1S)-2-oxo-2-({2-oxo-2-[4-(3-pyridyloxy)-1-piperidinyl]ethyl}amino)-1-(2-pyridylmethyl)ethyl]-acrylamide (442198-32-5)

Guidance literature:

Reference yield:

2,5 dichloropyridine (16110-09-1) + tert-butyl 4-mercapto-1-piperidinecarboxylate (134464-79-2) → tert-butyl 4-[(5-chloro-2-pyridyl)thio]-1-piperidinecarboxylate (442199-32-8) + (2E)-3-(4-Chlorophenyl)-N-[(1S)-2-oxo-2-({2-oxo-2-[4-(3-pyridyloxy)-1-piperidinyl]ethyl}amino)-1-(2-pyridylmethyl)ethyl]-acrylamide (442198-32-5)

Guidance literature:

Reference yield:

3-chloro-6-methoxypyridazine (1722-10-7) + t-butyl 4-hydroxy piperidine-1-carboxylate (109384-19-2) → tert-butyl 4-((6-methoxypyridazin-3-yl)oxy)piperidine-1-carboxylate (442199-17-9) + (2E)-3-(4-Chlorophenyl)-N-[(1S)-2-oxo-2-({2-oxo-2-[4-(3-pyridyloxy)-1-piperidinyl]ethyl}amino)-1-(2-pyridylmethyl)ethyl]-acrylamide (442198-32-5)

Guidance literature:

upstream raw materials:

2,5 dichloropyridine

tert-butyl 4-mercapto-1-piperidinecarboxylate

3-chloro-6-methoxypyridazine

t-butyl 4-hydroxy piperidine-1-carboxylate