BUTTPARK 78\40-96

Base Information

• Chemical Name: BUTTPARK 78\40-96
• CAS No.: 329699-54-9
• Molecular Formula: C14H13ClN2O3S
• Molecular Weight: 324.788
• Mol file: 329699-54-9.mol

Synonyms:[2-(4-chloro-benzoylamino)-thiazol-4-yl]-acetic acid ethyl ester;ETHYL {2-[(4-CHLOROBENZOYL)AMINO]-1,3-THIAZOL-4-YL}ACETATE;

Chemical Property of BUTTPARK 78\40-96

Chemical Property:

• PSA: 96.53000
• LogP: 3.22740

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of BUTTPARK 78\40-96

There total 2 articles about BUTTPARK 78\40-96 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

ethyl 2-amino-1,3-thiazol-4-acetate (53266-94-7) + 4-chloro-benzoyl chloride (122-01-0) → 2-[[(4-chlorophenyl)carbonyl]amino]-1,3-thiazol-4-yl-acetic acid ethyl ester (329699-54-9)

Guidance literature:

With pyridine; at 120 ℃; Cooling with ice;

DOI:10.1002/ardp.200700046

Reference yield:

ethyl 2-amino-1,3-thiazol-4-acetate (53266-94-7) + para-chlorobenzoic acid (74-11-3) → 2-[[(4-chlorophenyl)carbonyl]amino]-1,3-thiazol-4-yl-acetic acid ethyl ester (329699-54-9)

Guidance literature:

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 3 - 24h;

Reference yield: 22.0%

ethyl bromide (74-96-4) + 2-[[(4-chlorophenyl)carbonyl]amino]-1,3-thiazol-4-yl-acetic acid ethyl ester (329699-54-9) → ethyl 2-(2-(4-chloro-N-ethylbenzamido)thiazol-4-yl)acetate

Guidance literature:

2-[[(4-chlorophenyl)carbonyl]amino]-1,3-thiazol-4-yl-acetic acid ethyl ester; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 20h;

ethyl bromide; In N,N-dimethyl-formamide; at 90 ℃; for 3h;

DOI:10.1016/j.bmcl.2020.127473

upstream raw materials:

ethyl 2-amino-1,3-thiazol-4-acetate

para-chlorobenzoic acid

4-chloro-benzoyl chloride

Downstream raw materials:

2-(4-chlorobenzamido)thiazol-4-acetic acid

N-[3-(cyclohexylamino)propyl]-2-[[(4-chlorophenyl)carbonyl]amino]-1,3-thiazol-4-yl-acetamide