5-Chloro-3-Methyl-2-phenyl-1H-indole

Base Information

• Chemical Name: 5-Chloro-3-Methyl-2-phenyl-1H-indole
• CAS No.: 41018-94-4
• Molecular Formula: C15H12ClN
• Molecular Weight: 241.72
• Mol file: 41018-94-4.mol

Synonyms:

Chemical Property of 5-Chloro-3-Methyl-2-phenyl-1H-indole

Chemical Property:

• Storage Temp.: 2-8°C

Purity/Quality:

95+% ^*data from raw suppliers

5-Chloro-3-methyl-2-phenyl-1H-indole 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Chloro-3-Methyl-2-phenyl-1H-indole

There total 8 articles about 5-Chloro-3-Methyl-2-phenyl-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-chlorophenylhydrazine hydrochloride (1073-70-7) + 1-phenyl-propan-1-one (93-55-0) → 5-chloro-3-methyl-2-phenyl-1H-indole (41018-94-4)

Guidance literature:

at 250 ℃; for 0.0166667h;

DOI:10.1515/HC.2003.9.1.9

Reference yield: 76.0%

1-Phenylprop-1-yne (673-32-5) + 4-chlorophenylhydrazine hydrochloride (1073-70-7) → 5-chloro-3-methyl-2-phenyl-1H-indole (41018-94-4)

Guidance literature:

With dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; sodium acetate; acetic acid; pentan-3-one; In ethanol; at 110 ℃; for 20h; regioselective reaction; Sealed tube; Inert atmosphere;

DOI:10.1002/adsc.201400224

Reference yield: 65.0%

1-Phenylprop-1-yne (673-32-5) + (E)-1-((4-chlorophenyl)diazenyl)pyrrolidine (62499-16-5) → 5-chloro-3-methyl-2-phenyl-1H-indole (41018-94-4)

Guidance literature:

With silver hexafluoroantimonate; dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; copper(II) acetate monohydrate; In methanol; at 90 ℃; regioselective reaction; Schlenk technique; Inert atmosphere;

DOI:10.1002/anie.201301742

upstream raw materials:

4-chlorophenylhydrazine hydrochloride

1-phenyl-propan-1-one

styrene

carbon monoxide

Downstream raw materials:

benzoic acid-(2-acetyl-4-chloro-anilide)

Refernces

• 1、 Zeng, Fan-Lin,Sun, Kai,Chen, Xiao-Lan,Yuan, Xiao-Ya,He, Shuai-Qi,Liu, Yan,Peng, Yu-Yu,Qu, Ling-Bo,Lv, Qi-Yan,Yu, Bing. "Metal-Free Visible-Light Promoted Radical Cyclization to Access Perfluoroalkyl-Substituted Benzimidazo[2,1-a]isoquinolin-6(5H)-ones and Indolo[2,1-a]isoquinolin-6(5H)-ones". supporting information. p. 5176 - 5181. Retrieved 2019/11/11.
• 2、 Muralirajan, Krishnamoorthy,Cheng, Chien-Hong. "Regioselective synthesis of indoles via rhodium-catalyzed C-H activation directed by an in-situ generated redox-neutral group". . p. 1571 - 1576. Retrieved 2014/06/09.