1-tert-Butyl-piperidin-4-one

Base Information

Chemical Name:1-tert-Butyl-piperidin-4-one
CAS No.:1465-76-5
Molecular Formula:C9H17NO
Molecular Weight:155.24
Hs Code.:2933399990
European Community (EC) Number:215-982-8
DSSTox Substance ID:DTXSID20163383
Nikkaji Number:J206.670J
Wikidata:Q72504121
Mol file:1465-76-5.mol

Synonyms:1465-76-5;1-tert-Butyl-piperidin-4-one;1-tert-butylpiperidin-4-one;1-(tert-Butyl)piperidin-4-one;1-tert-Butyl-4-piperidone;1-tert-Butyl-4-piperidinone;EINECS 215-982-8;4-PIPERIDINONE, 1-(1,1-DIMETHYLETHYL)-;MFCD03411608;4-Piperidinone,1-(1,1-dimethylethyl)-;N-t-butyl-4-piperidone;1-t-Butyl-4-piperidone;1-tert-butyl-piperid-4-one;1-(t-butyl)piperidin-4-one;1-tert-Butylpiperidine-4-one;SCHEMBL141779;1-tert -butylpiperidin-4-one;1-tert-Butyl-4-Oxopiperidine;1-tert-butyl-4-oxo-piperidine;DTXSID20163383;1-tert-Butyl-4-piperidone, 97%;AKOS000179329;AB14177;CS-W001443;PS-3488;1-(1,1-dimethylethyl)-4-piperidinone;AC-18691;FT-0684954;EN300-60262;A884498;W-205640;Z295881938

Suppliers and Price of 1-tert-Butyl-piperidin-4-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
1-tert-Butylpiperidin-4-one
50mg
$ 45.00

SynQuest Laboratories
1-(tert-Butyl)piperidin-4-one 98%
250 mg
$ 29.00

SynQuest Laboratories
1-(tert-Butyl)piperidin-4-one 98%
1 g
$ 82.00

Sigma-Aldrich
1-tert-Butyl-4-piperidone 97%
1g
$ 215.00

Matrix Scientific
1-tert-Butylpiperidin-4-one >95%
5g
$ 1250.00

Matrix Scientific
1-tert-Butylpiperidin-4-one >95%
1g
$ 265.00

Crysdot
1-(tert-Butyl)piperidin-4-one 97%
1g
$ 71.00

Crysdot
1-(tert-Butyl)piperidin-4-one 97%
5g
$ 228.00

Crysdot
1-(tert-Butyl)piperidin-4-one 97%
25g
$ 798.00

Crysdot
1-(tert-Butyl)piperidin-4-one 97%
10g
$ 399.00

Total 35 raw suppliers

Chemical Property of 1-tert-Butyl-piperidin-4-one

Chemical Property:

Vapor Pressure:0.0883mmHg at 25°C
Melting Point:92-94 °C (sublm)(Press: 10 Torr)
Refractive Index:1.472
Boiling Point:225 °C at 760 mmHg
PKA:8.26±0.20(Predicted)
Flash Point:83.5 °C
PSA：20.31000
Density:0.968 g/cm³
LogP:1.38770
Storage Temp.:Inert atmosphere,Room Temperature
XLogP3:0.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:155.131014166
Heavy Atom Count:11
Complexity:147

Purity/Quality:

97% ^*data from raw suppliers

1-tert-Butylpiperidin-4-one ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:CC(C)(C)N1CCC(=O)CC1
General Description 1-TERT-BUTYL-PIPERIDIN-4-ONE is a key intermediate in the synthesis of pharmaceutical compounds, such as p38 MAP kinase inhibitors, where it serves as a precursor for Grignard reactions. Its efficient preparation via transamination is facilitated by trapping dimethylamine with sodium acrylate, enabling high-yield production and simplified purification. 1-TERT-BUTYL-PIPERIDIN-4-ONE is particularly valuable in large-scale drug synthesis, as demonstrated in the development of therapeutics for rheumatoid arthritis and psoriasis.

Technology Process of 1-tert-Butyl-piperidin-4-one

There total 13 articles about 1-tert-Butyl-piperidin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%