2-Isopropylmalonic acid dimethyl ester

Base Information

• Chemical Name: 2-Isopropylmalonic acid dimethyl ester
• CAS No.: 51122-91-9
• Molecular Formula: C8H14O4
• Molecular Weight: 174.197
• Hs Code.: 2917190090
• Mol file: 51122-91-9.mol

Synonyms:Isopropylmalonsaeure-dimethylester;methyl 2-carbomethoxy-3-methylbutyrate;dimethyl 2-isopropyl malonate;isopropyl-malonic acid dimethyl ester;

Chemical Property of 2-Isopropylmalonic acid dimethyl ester

Chemical Property:

• PSA: 52.60000
• LogP: 0.60460
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

≥97% ^*data from raw suppliers

Dimethyl2-isopropylmalonate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Isopropylmalonic acid dimethyl ester

There total 12 articles about 2-Isopropylmalonic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

2-iodo-propane (75-30-9) + malonic acid dimethyl ester (108-59-8) → dimethyl isopropylmalonate (51122-91-9)

Guidance literature:

With sodium hydride; In tetrahydrofuran;

DOI:10.1016/S0040-4039(00)74134-7

Reference yield: 89.0%

methanol (67-56-1) + dimethyl isopropylidenemalonate (22035-53-6) → dimethyl isopropylmalonate (51122-91-9) + dimethyl 3,3-dimethoxybutane-1,1-dicarboxylate (133494-04-9)

Guidance literature:

With sodium iodide; at 60 ℃; 2.8 F/mol of the electricity;

DOI:10.1016/S0040-4020(98)00912-0

Reference yield: 86.0%

dimethyl isopropylidenemalonate (22035-53-6) → dimethyl isopropylmalonate (51122-91-9)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; for 7h; under 760 Torr;

DOI:10.1016/S0957-4166(00)82251-X

upstream raw materials:

methanol

isopropylmalonic acid

propene

dimethyl malonate sodium salt

Downstream raw materials:

2-isopropylpropan-1,3-diol

(4E)-5-chloro-2-isopropyl-4-pentenoic acid

methyl (4E)-5-chloro-2-isopropyl-4-pentenoate

isopropylmalonic acid

Refernces

• 1、 Klahn, Philipp,Erhardt, Hellmuth,Kotthaus, Andreas,Kirsch, Stefan F.. "The synthesis of α-azidoesters and geminal triazides". supporting information. p. 7913 - 7917. Retrieved 2014/08/05.
• 2、 -. "PROCESSES FOR PRODUCING (4E)-5-CHLORO-2-ISOPROPYL-4-PENTENOIC ESTER AND OPTICALLY ACTIVE ISOMER THEREOF". Page/Page column 11. . Retrieved 2008/06/13.